Supraspinal Processing of Sensory Aspects of Pain

Part of paid clinical trials in Cincinnati, Ohio.

Sponsor
Children's Hospital Medical Center, Cincinnati
Study ID
NCT05814497
Status
Recruiting
Apply to this trial

Conditions

  • Complex Regional Pain Syndromes
  • Fibromyalgia
  • Functional Abdominal Pain Syndrome
  • Migraine in Children
  • Musculoskeletal Pain

Eligibility Criteria

Sex
ALL
Age
10 Years - 17 Years
Healthy Volunteers
Accepted

Interventions

  • Multisensory Task — OTHER
    Reversing checkerboard, tones, and finger opposition.
  • Graphesthesia — OTHER
    Trace numbers on skin.
  • Divided attention — OTHER
    Divide attention between two noxious stimuli.

Study Details

The goal of this basic science study is to learn about the brain mechanisms of chronic pain across different chronic pain syndromes in pediatric patients. The main questions it aims to answer are: * Are there shared and distinct brain systems engaged by different forms of pediatric chronic pain? * What are predictors of recovery from chronic pain? * What brain systems are associated with the spread of pain? For this study participants will undergo: * Functional Magnetic Resonance Imaging (fMRI) * Quantitative Sensory Testing * Psychological Assessments

Key Dates

Start date
May 1, 2023
Status verified
Jun 2026
Primary completion
Jun 30, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
255 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Healthy Controls
    Healthy controls with no history of chronic pain.
  • Experimental: Headache and Migraine
    Individuals who have migraine with headaches.
  • Experimental: Functional Abdominal Pain Disorder (FAPD)
    Individuals who have functional abdominal pain disorder.
  • Experimental: Localized and Diffuse/Widespread Musculoskeletal Pain (MSK)
    Individuals with chronic musculoskeletal pain.
  • Experimental: Complex Regional Pain Syndrome (CRPS)
    Individuals with complex regional pain syndrome.

Primary Outcome Measure

FMRI: BOLD resting connectivity of the amygdala [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Cincinnati Children's HospitalCincinnatiOhio45229
Catherine Jackson, MSc
[email protected]
513-636-0669
Hannah Schildmeyer, BS
[email protected]
Robert Coghill, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Cincinnati, OH

By research site
Cincinnati Children's Hospital· Cincinnati, OH

Related Studies