The Role of Macrophage Activation in Lung Injury Following Ozone Exposure

Part of paid clinical trials in Piscataway, New Jersey.

Sponsor
Rutgers, The State University of New Jersey
Study ID
NCT05794087
Status
Recruiting
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Conditions

  • Air Pollution

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Clean Air — OTHER
    Subjects will be exposed to clean air for 3 hours.
  • Ozone — OTHER
    Subjects will be exposed to 0.2 ppm ozone for 3 hours.

Study Details

The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. The exposure visits will be at least 2 weeks apart. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.

Key Dates

Start date
Feb 7, 2023
Status verified
Dec 2025
Primary completion
Jun 1, 2027
Completion
Jun 1, 2027

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Clean Air, Then Ozone
    Subjects will be exposed to clean air for 3 hours at the first exposure visit and 0.2ppm ozone for 3 hours at the second exposure visit. The visits will be at least 2 weeks apart.
  • Experimental: Ozone, Then Clean Air
    Subjects will be exposed to 0.2 ppm ozone for 3 hours at the first exposure visit and clean air for 3 hours at the second exposure visit. The visits will be at least 2 weeks apart.

Primary Outcome Measure

Metabolic activity of inflammatory cells in induced sputum [ Time Frame: Within 3 days of exposure ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Rutgers - EOHSIPiscatawayNew Jersey08854
Kathy Black, PhD
[email protected]
848-445-6049
Adriana De Resende
[email protected]
848-445-0178

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Rutgers - EOHSI· Piscataway, NJ

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