Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of Southern California
Study ID
NCT05867381
Status
Recruiting
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Conditions

  • Air Pollution
  • Atherosclerosis

Eligibility Criteria

Sex
ALL
Age
65 Years - 84 Years
Healthy Volunteers
Not accepted

Interventions

  • HEPA filtration — DEVICE
    HEPA filters with the capacity to reduce PM2.5 levels
  • Sham filtration — DEVICE
    Sham filtration use the same appearance of air purifier but with HEPA filter removed.

Study Details

This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.

Key Dates

Start date
Jul 11, 2023
Status verified
Jun 2026
Primary completion
Jun 30, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
112 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION

Arms

  • Experimental: HEPA first and sham
    This group of participants will be assigned to the intervention of HEPA filtration with the capacity to reduce indoor PM2.5 levels at their residence for 9 months first. After 3-month wash-out period, participants will be assigned to sham filters (air purifier has the same appearance but HEPA filter is removed) for 9 months.
  • Experimental: Sham first and HEPA
    This group of participants will be assigned to the intervention of sham filtration with HEPA filter removed at their residence for 9 months first. After 3-month wash-out period, participants will be assigned to the HEPA filtration for 9 months.

Primary Outcome Measure

Change in blood pressure [ Time Frame: Blood pressure will be monitored daily during each of the 9-month intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Keck School of Medicine, University of Southern CaliforniaLos AngelesCalifornia90033
Zhanghua Chen, PhD
[email protected]
323-442-2109

Find similar trials in Los Angeles, CA

By research site
Keck School of Medicine, University of Southern California· Los Angeles, CA

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