HEPA, PM2.5, and Cardiometabolic Health

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of Southern California
Study ID
NCT05718245
Status
Recruiting
Apply to this trial

Conditions

  • Air Pollution
  • Cardiometabolic Health

Eligibility Criteria

Sex
ALL
Age
65 Years - 84 Years
Healthy Volunteers
Accepted

Interventions

  • HEPA filter — DEVICE
    HEPA filters with the capacity to reduce PM2.5 levels
  • Sham filter — DEVICE
    sham filters without the capacity to reduce PM2.5 levels

Study Details

The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.

Key Dates

Start date
Mar 15, 2023
Status verified
Jul 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
52 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION

Arms

  • Experimental: HEPA first and sham
    This group of participants will be assigned an intervention of HEPA filters with the capacity to reduce PM2.5 levels at their residence for 6 months. After 6-month wash-out period, will be assigned to sham filters for 6 months.
  • Sham Comparator: Sham first and HEPA
    This group of participants will be assigned an intervention of sham filters without the capacity to reduce PM2.5 levels at their residence for 6 months. After 6-month wash-out period, will be assigned to HEPA filters for 6 months.

Primary Outcome Measure

Change in HOMA-IR [ Time Frame: At the baseline and immediately after each of the 6-month interventions ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Keck School of Medicine, University of Southern CaliforniaLos AngelesCalifornia90033
Zhanghua Chen, PhD
[email protected]
323-442-2109

Find similar trials in Los Angeles, CA

By research site
Keck School of Medicine, University of Southern California· Los Angeles, CA

Related Studies