Macrophage Regulation of Ozone-Induced Lung Inflammation

Part of paid clinical trials in Durham, North Carolina.

Sponsor
Robert Tighe, MD
Study ID
NCT05773001
Phase
PHASE1
Status
Recruiting
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Conditions

  • Respiratory Viral Infection

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Ozone — DRUG
    Subjects will perform alternating 15 minutes rest with 15 minutes treadmill walk exercise periods for 135 minutes in while breathing Ozone (O3).

Study Details

The purpose of this research study to understand how prior respiratory infections affect the susceptibility to lung inflammation following environmental exposures.

Key Dates

Start date
May 18, 2023
Status verified
May 2026
Primary completion
May 31, 2028
Completion
May 31, 2028

Study Design

Enrollment
100 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Other: Cohort 1
    no history of respiratory viral infection
  • Other: Cohort 2
    Documented mild respiratory viral infection
  • Other: Cohort 3
    Respiratory viral pneumonia

Primary Outcome Measure

Change in the abundance of monocyte-derived alveolar macrophages [ Time Frame: Baseline, Day 18-20 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Duke University Medical CenterDurhamNorth Carolina27710
Claudia Salazar, BS
[email protected]
919-660-2026
Robert Tigher, MD (PRINCIPAL_INVESTIGATOR)

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By research site
Duke University Medical Center· Durham, NC

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