Stereotactic Adaptive Radiation Therapy of Borderline Resectable Pancreatic Cancer an Individualized Approach

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Varian, a Siemens Healthineers Company
Study ID
NCT05764720
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Daily Adaptive External Beam Radiation Therapy — RADIATION
    Daily adaptive external beam radiation therapy delivered on Varian Ethos treatment system.

Study Details

This trial is a single-arm, prospective, multi-center clinical trial designed to demonstrate that stereotactic adaptive radiotherapy using an ablatively dosed (50Gy,5fx) for treatment of borderline-resectable, locally-advanced , or medically inoperable pancreatic adenocarcinoma will translate into a decreased toxicity. The study will evaluate GI toxicity, overall survival, local control, quality of life, and workflow metrics.

Key Dates

Start date
May 14, 2023
Status verified
Mar 2026
Primary completion
Mar 31, 2028
Completion
Mar 15, 2030

Study Design

Enrollment
134 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Daily Adaptive External Beam Radiation Therapy
    Daily adaptive radiation therapy delivered with Varian Ethos treatment system

Primary Outcome Measure

Acute Grade 3+ treatment related GI toxicities [ Time Frame: Within 90 days from start of treatment ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
University of Alabama at BirminghamBirminghamAlabama35205
Gobind Gill, MD
[email protected]
205-996-1087
Gobind Gill, MD (PRINCIPAL_INVESTIGATOR)
Washington University, St. LouisSt LouisMissouri63130
Michael Waters, MD PhD
[email protected]
571-232-8050
Michael Waters, MD PhD (PRINCIPAL_INVESTIGATOR)
UH Cleveland Medical CenterClevelandOhio44106
Lauren Henke, MD
[email protected]
218-234-6429
Lauren Henke, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Birmingham, AL

By condition
Pancreatic cancer
By specialty
OncologyGI oncology
By research site
University of Alabama at Birmingham· Birmingham, ALWashington University, St. Louis· St Louis, MOUH Cleveland Medical Center· Cleveland, OH

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