Dinner Time for Obesity and Prediabetes

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT05745441
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Early Dinner — BEHAVIORAL
    Dinner before DLMO
  • Late Dinner — BEHAVIORAL
    Dinner after DLMO
  • Early Dinner tracer — DRUG
    Stable isotope of oral \[2H31\] palmitate to measure fat oxidation, given with dinner before DLMO
  • Late Dinner tracer — DRUG
    Stable isotope of oral \[2H31\] palmitate to measure fat oxidation, given with dinner after DLMO

Study Details

Obesity and its metabolic complications are leading causes of global morbidity and mortality. Evidence is mounting that inappropriate timing of food intake contributes to obesity. Specifically, late eating is associated with greater weight gain and metabolic syndrome. However, the mechanism by which late eating harms metabolism is not fully understood but may be related to mis-timing of food intake in relation to the body's endogenous circadian rhythm. Conversely, harmonization of eating timing with endogenous circadian rhythm may optimize metabolic health. In this study the investigators will use gold-standard methods of characterizing circadian rhythm in humans to examine the metabolic impacts food timing relative to endogenous circadian rhythm.

Key Dates

Start date
Jul 5, 2023
Status verified
Apr 2026
Primary completion
Mar 31, 2028
Completion
Mar 31, 2028

Study Design

Enrollment
32 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Early Dinner First
    Participants will be served dinner and a stable isotope of oral \[2H31\] palmitate to measure fat oxidation, at an early dinner time (before DLMO). This arm will then cross-over to Late Dinner as the second metabolic visit.
  • Experimental: Late Dinner First
    Participants will be served dinner and a stable isotope of oral \[2H31\] palmitate to measure fat oxidation, at a late dinner time (after DLMO). This arm will then cross-over to Early Dinner as the second metabolic visit.

Primary Outcome Measure

24-hour total fat oxidation [ Time Frame: baseline, 4 weeks ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Johns Hopkins Bayview Medical CenterBaltimoreMaryland21224
Athena Mavronis
[email protected]
410-550-4588
Jonathan Jun, MD
[email protected]
410-550-0115
Jonathan Jun, MD (PRINCIPAL_INVESTIGATOR)
Daisy Duan, MD (SUB_INVESTIGATOR)
Luu Pham, MD (SUB_INVESTIGATOR)
National Institutes of Health Clinical CenterBethesdaMaryland20892
Stephanie T Chung, MBBS
[email protected]
240-479-8137
Lilian Mabundo, RN, MSN
[email protected]
240-383-9379
Stephanie T Chung, MBBS (PRINCIPAL_INVESTIGATOR)
Kong Y Chen, PhD (SUB_INVESTIGATOR)

Find similar trials in Baltimore, MD

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Johns Hopkins Bayview Medical Center· Baltimore, MDNational Institutes of Health Clinical Center· Bethesda, MD

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