Neuro-affective Response to Light in Depressed Adolescents and Young Adults

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
University of Pittsburgh
Study ID
NCT05712772
Status
Recruiting
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Conditions

  • Depression in Adolescence
  • Depression in Adults

Eligibility Criteria

Sex
ALL
Age
12 Years - 30 Years
Healthy Volunteers
Not accepted

Interventions

  • Blue Light — OTHER
    Blue light exposure
  • Red Light — OTHER
    Red light exposure

Study Details

The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in depression. The main questions this study aims to answer are: * Does acute exposure to blue light (vs red light) stabilize emotional brain function in depressed individuals? * Are stabilizing effects of blue light (vs red light) stronger for blue light in adolescents than young adults? Participants will complete: * A magnetic resonance imaging brain scan, in which we will examine the effect of blue versus red light on emotional brain function at rest and in response to rewards and losses. * A pupillometry test of sensitivity to blue vs red light * Clinical interviews and surveys * Screening measures for drug and alcohol use, MRI safety, and current pregnancy \[if relevant\] * Home sleep tracking with sleep diary and actigraphy for one week

Key Dates

Start date
Jun 14, 2023
Status verified
Aug 2025
Primary completion
Jul 31, 2026
Completion
Jul 31, 2026

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Experimental: Blue then Red Light
    Blue light (480 nm) then Red light (640 nm)
  • Experimental: Red Light then Blue Light
    Red light (640 nm) then Blue light (480 nm)

Primary Outcome Measure

Amygdala cerebral blood flow during Blue vs Red light exposure [ Time Frame: Collected during the blue and red light exposures during the MRI scan at the lab visit ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Western Psychiatric HospitalPittsburghPennsylvania15213
Allison Caswell
[email protected]
412-246-6652
Adriane M Soehner, PhD (PRINCIPAL_INVESTIGATOR)
Henry Chase, PhD (SUB_INVESTIGATOR)
Kathryn Roecklein, PhD (SUB_INVESTIGATOR)

Find similar trials in Pittsburgh, PA

By research site
Western Psychiatric Hospital· Pittsburgh, PA

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