A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT05699200
Status
Recruiting
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Conditions

  • Healthy
  • Spontaneous Coronary Artery Dissection

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Arterial Tonometry — OTHER
    We will measure arterial stiffness using arterial tonometry.
  • Echocardiogram — DIAGNOSTIC_TEST
    We will collect limited ultrasound images of the heart.
  • Carotid Ultrasounds — DIAGNOSTIC_TEST
    We will perform ultrasound imaging of the carotid artery.
  • Elastography — DIAGNOSTIC_TEST
    We will measure the elastic properties of the arteries using elastography.
  • Ankle-Brachial Index — OTHER
    We will measure the ankle-brachial index to assess peripheral artery blood flow.
  • Microneurography with sympathoexcitatory maneuvers — OTHER
    We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.

Study Details

The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

Key Dates

Start date
Jun 1, 2023
Status verified
Jun 2025
Primary completion
Aug 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
50 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH

Arms

  • Other: Spontaneous coronary artery dissection (SCAD) group
    Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
  • Other: Healthy Control Group
    Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.

Primary Outcome Measure

Arterial thickness [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic RochesterRochesterMinnesota55905-

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By research site
Mayo Clinic Rochester· Rochester, MN

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