Ventral Capsulotomy for Intractable OCD

Part of paid clinical trials in Providence, Rhode Island.

Sponsor
Butler Hospital
Study ID
NCT05659082
Phase
PHASE3
Status
Enrolling By Invitation

Conditions

  • Obsessive-Compulsive Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - 90 Years
Healthy Volunteers
Not accepted

Interventions

  • Laser Interstitial Thermal Therapy — DEVICE
    Ventral capsulotomy for OCD using laser interstitial thermal therapy

Study Details

Obsessive-compulsive disorder impacts 1-2 percent of the population. Unfortunately, about fifteen percent of patients fail to benefit from existing therapies. A small number of OCD patients, who have a disabling illness that does not improve after conventional treatments, have neurosurgery as a last resort. One procedure, capsulotomy, involves making pairs of lesions in an anatomically-defined part of the anterior limb of the internal capsule, a structure containing nerve fiber bundles connecting the thalamus, in the center of the brain, to the prefrontal cortex, the most anterior and outermost brain region. The investigators will examine how the therapeutic effects of capsulotomy relate to changes in the structure of these brain pathways with structural (diffusion tensor imaging, DTI) and functional (resting-state and task-based) connectivity metrics. The investigators will also utilize experimental cognitive tasks that are sensitive to the circuitry impacted by this procedure.

Key Dates

Start date
Jun 21, 2022
Status verified
Jan 2023
Primary completion
Dec 31, 2032
Completion
Dec 31, 2032

Study Design

Enrollment
50 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Primary Outcome Measure

Yale-Brown Obsessive-Compulsive Scale (YBOCS) [ Time Frame: 12 months ]

Locations (1)

FacilityCityStateZIPSite coordinators
Butler HospitalProvidenceRhode Island02906-

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By research site
Butler Hospital· Providence, RI

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