Locating Biomarkers in OCD Through Behavioral Tasks

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Baylor College of Medicine
Study ID
NCT03313622
Status
Not Yet Recruiting

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Conditions

  • OCD
  • Obsessive-Compulsive Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Beads Task — BEHAVIORAL
    Participants will be asked to make a series of decisions that involve combining information about the value and probability of potential rewards. Subjects will sit in front of a computer monitor and place their hand over a box with orange and blue button that they will be asked to press based on their idea of which one will be the majority in a jar full of orange and blue beads. This task should take 15-20 minutes to complete, not including EEG setup.
  • PROVOC Tasks — BEHAVIORAL
    Three tasks will be developed collaboratively with the participant and independent evaluator that involve the participant being exposed to triggers that are considered by him/her impossible to confront without ritualizing. There will also be a similar process involving objects that should not cause any distress to be used as a control. Sessions will be videotaped with AFAR system concurrent to recording of LFPs from VS and scalp EEG.

Study Details

Subjects that have a diagnosis of OCD will participate in a clinical interview and cognitive tasks, during which they will be exposed to their individual OC stressors or will be asked to make decisions related to information value and quantity while measuring neural activity and filming facial reactions. This will assist investigators to look for biomarkers of that change. This study offers a unique opportunity to develop biomarkers for key domains of OCD, and other neuropsychiatric disorders, that are grounded in brain neurocircuitry at the individual-patient level. Subjects will participate in a clinical interview (Day 1), and then tasks+EEG (Day 2). Day 1 will be 4 hours or less, and Day 2 will be 2.5 hours or less.

Key Dates

Start date
Mar 31, 2026
Status verified
Jul 2025
Primary completion
Mar 31, 2026
Completion
Mar 31, 2026

Study Design

Enrollment
20 participants (estimated)

Arms

  • Arm: OCD group
    Day 1: Questionnaires/Assessments Day 2: Tasks

Primary Outcome Measure

Investigate for biomarkers of obsessive compulsive disorder pathophysiology through the use of behavioral tasks - Beads task [ Time Frame: Day 2 ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
University of PittsburghPittsburghPennsylvania15260-
Brown UniversityProvidenceRhode Island02912-
Baylor College of MedicineHoustonTexas77030
Clarissa Aguilar
[email protected]
(713) 798-3080
Gregory Vogt
[email protected]
(713) 798-4729
Wayne K Goodman, MD (PRINCIPAL_INVESTIGATOR)
Raymond Cho, MD, PhD (SUB_INVESTIGATOR)
Nithya Ramakrishnan, MS (SUB_INVESTIGATOR)
Eric Storch, PhD (SUB_INVESTIGATOR)
Elizabeth McIngvale, PhD (SUB_INVESTIGATOR)
Gregory Vogt (SUB_INVESTIGATOR)

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