Determining the Role of Social Reward Learning in Social Anhedonia

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
University of Alabama at Birmingham
Study ID
NCT05617898
Status
Recruiting
Apply to this trial

Conditions

  • Psychosis

Eligibility Criteria

Sex
ALL
Age
18 Years - 35 Years
Healthy Volunteers
Not accepted

Interventions

  • Motivational Interviewing — BEHAVIORAL
    Three motivational interviewing sessions will target sensitivity to social reward, including subjective evaluation of social interaction, socially rewarding stimuli, and events (e.g., interactions with others, feedback from others).
  • Nutrition Didactic Training — BEHAVIORAL
    The Nutrition didactic training will ask participants to discuss pros and cons of healthy eating habits and how to improve their current eating habits.

Study Details

This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be randomized 1:1 to motivational interviewing or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. With this design feature, we will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels.

Key Dates

Start date
Jun 14, 2023
Status verified
Jul 2025
Primary completion
Nov 30, 2027
Completion
Nov 30, 2027

Study Design

Enrollment
152 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Motivational Interview Intervention
    This arm involves three 45-minute sessions on motivational interviewing targeting sensitivity to social reward.
  • Active Comparator: Active Control Intervention
    This arm involves three 45-minute sessions on didactic training on nutrition.

Primary Outcome Measure

Response Bias [ Time Frame: 3 weeks ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
University of Alabama at BirminghamBirminghamAlabama35294
Andrew Meddaugh, BA
[email protected]
205-934-8203
Junghee Lee, PhD
[email protected]
205-934-8205
Junghee Lee, PhD (PRINCIPAL_INVESTIGATOR)
Adrienne C Lahti, MD (SUB_INVESTIGATOR)
Alison Thomas, PhD (SUB_INVESTIGATOR)
Caitlin W Clevenger, PhD (SUB_INVESTIGATOR)
Gerhard S Hellemann, PhD (SUB_INVESTIGATOR)
University of California Los AngelesLos AngelesCalifornia90095
Rebecca Zornitsky, MS
[email protected]
424-225-1779
Joseph Ventura, PhD
[email protected]
310-206-3142
Keith H Nuechterlein, PhD (PRINCIPAL_INVESTIGATOR)
Michael F Green, PhD (PRINCIPAL_INVESTIGATOR)
Joseph Ventura, PhD (SUB_INVESTIGATOR)
Kenneth Subotnik, PhD (SUB_INVESTIGATOR)
Amy M Jimenez, PhD (SUB_INVESTIGATOR)
Lena M Reddy, PhD (SUB_INVESTIGATOR)

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