Enhancing Rehabilitation for Veterans With Serious Mental Illness

Part of paid clinical trials in San Diego, California.

Sponsor
VA Office of Research and Development
Study ID
NCT06586164
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 83 Years
Healthy Volunteers
Not accepted

Interventions

  • Targeted Cognitive Training — BEHAVIORAL
    TCT is a computer-based cognitive training program in which participants train on progressively more difficult auditory processing exercises in order to improve speed, accuracy and fidelity of auditory information processing in order to generate gains in cognition and functioning.

Study Details

This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs). The vast majority of individuals with SMI suffer from cognitive impairments, leading to chronic functional disability, and impaired outcomes, causing a significant strain on support networks and the VA healthcare system. This study aims to introduce an innovative mental health therapy, Targeted Cognitive Training (TCT), to Veterans struggling with serious mental illnesses (SMI). TCT works to improve basic sensory information processing and, ultimately, clinical, cognitive, and psychosocial functioning. By using EEG biomarkers to identify Veterans with SMI receiving care within VA Psychosocial Rehabilitation and Recovery Centers who are most likely to benefit from this treatment, and by understanding how best to implement this therapy, the investigators hope to enhance care and improve life quality for Veterans with SMI.

Key Dates

Start date
Feb 25, 2025
Status verified
Jan 2026
Primary completion
Aug 31, 2028
Completion
Oct 31, 2028

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: TCT + TAU
    Subjects will complete 30 hours of Targeted Cognitive Training (TCT) in addition to their Treatment as Usual (TAU)
  • No Intervention: TAU
    Subjects will participate in their standard Treatment as Usual (TAU) PRRC program

Primary Outcome Measure

Clinical Symptoms - Positive and Negative Syndrome Scale (PANSS) [ Time Frame: 22 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
VA San Diego Healthcare System, San Diego, CASan DiegoCalifornia92161-0002
Gregory Light, PhD
[email protected]
619-227-4734
Yash B Joshi, MD PhD
[email protected]
(858) 642-3827
Gregory Light, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
VA San Diego Healthcare System, San Diego, CA· San Diego, CA

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