Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT05525845
Status
Recruiting
Apply to this trial

Conditions

  • Healthy

Eligibility Criteria

Sex
ALL
Age
21 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Functional Magnetic Resonance Imaging (pCASL-MRI) — OTHER
    MRI's will be performed at multiple points on each visit day.
  • Intragastric Balloon — OTHER
    Intragastric Balloon will be placed during Visit 2 study day and inflated to maximum tolerated volume. Patient will then be scanned in the MRI.
  • Elemental Meal — OTHER
    Patient will ingest the tasteless elemental meal until their maximum level of fullness. Once full, the patient will be scanned in the MRI.
  • Hedonic Meal — OTHER
    Patient will ingest meal of their choice from a local food delivery service and eat until they reach their maximum level of fullness. Once full, the patient will be scanned in the MRI

Study Details

The purpose of this study is to investigate how gut hormones and brain areas respond differently to gastric distention, tasteless calories, or palatable food and how this alters appetite.

Key Dates

Start date
Sep 8, 2022
Status verified
Sep 2025
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
15 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE

Arms

  • Other: Food-Print Main Arm
    Functional Magnetic Resonance Imaging (pCASL-MRI) after Caloric and Volumetric stimulus in lean patients will be performed on all patients in the study

Primary Outcome Measure

Difference in Cerebral Blood Flow related to hypothalamus [ Time Frame: 1 month ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic RochesterRochesterMinnesota55905-

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Mayo Clinic Rochester· Rochester, MN

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