Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)

Part of paid clinical trials in Dallas, Texas.

Sponsor
Rong Zhang
Study ID
NCT05331144
Phase
PHASE2
Status
Recruiting
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Conditions

  • Cognitively Normal Older Adults
  • Family History of Dementia
  • Hypertension
  • Subjective Cognitive Decline

Eligibility Criteria

Sex
ALL
Age
60 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Angiotensin II Receptor Blockers (ARBs, losartan) and Calcium Channel Blockers (CCB, amlodipine) — DRUG
    Angiotensin II Receptor Blockers (ARBs, losartan) and Calcium Channel Blockers (CCB, amlodipine) will be used to treat high blood pressure. Additional antihypertensive medications may be used if needed.
  • PCP — OTHER
    Participants will follow their PCP's recommendations for BP control.

Study Details

The purpose of this study is to determine if intensive lowering of systolic blood pressure (SBP), using FDA approved medications (antihypertensive), reduces Alzheimer's Disease pathology (i.e., excessive brain amyloid and tau protein deposition) in older adults at high risk for memory decline or dementia.

Key Dates

Start date
Oct 25, 2022
Status verified
Jul 2025
Primary completion
Jun 1, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
180 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Intensive Treatment (IT)
    Lowering SBP \< 120 mmHG
  • Active Comparator: Usual Care (UC)
    Participants will follow their PCP's recommendations for BP control

Primary Outcome Measure

Change From Baseline in Brain Fibrillar Beta-Amyloid Protein (Aβ) [ Time Frame: Baseline, 24 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Texas Southwestern Medical CenterDallasTexas75390
Tristyn Hall-Curtis, MBA
[email protected]
214-345-4245
Rong Zhang, PhD (PRINCIPAL_INVESTIGATOR)
Wanpen Vongpatanasin, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Dallas, TX

By condition
Hypertension (high blood pressure)
By specialty
CardiologyHeart disease
By research site
University of Texas Southwestern Medical Center· Dallas, TX

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