Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

Part of paid clinical trials in Dallas, Texas.

Sponsor
University of Texas Southwestern Medical Center
Study ID
NCT04838678
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Neuropeptide Y — DRUG
    intra-arterial infusion of neuropeptide Y

Study Details

The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.

Key Dates

Start date
Jul 18, 2021
Status verified
Aug 2025
Primary completion
Aug 31, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
100 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Healthy Control
    Healthy age matched controls with no history of cardiovascular disease and normal bodyweight
  • Experimental: Hypertensive
    Hypertensive adults who are not obese
  • Experimental: Obese
    Obese adults who are not hypertensive
  • Experimental: Obese-hypertensive
    Obese adults who are being treated for hypertension

Primary Outcome Measure

Blood flow measured by doppler ultrasound [ Time Frame: Acutely on the day of study ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Texas Southwestern Medical CenterDallasTexas75231
CHristopher Hearon
[email protected]
8155405612

Find similar trials in Dallas, TX

By condition
Hypertension (high blood pressure)Obesity / overweight
By specialty
CardiologyHeart diseaseEndocrinologyMetabolic healthWeight loss
By research site
University of Texas Southwestern Medical Center· Dallas, TX

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