Passive Heat Therapy for Lowering Systolic Blood Pressure and Improving Vascular Function in Mid-life and Older Adults

Part of paid clinical trials in Boulder, Colorado.

Sponsor
University of Colorado, Boulder
Study ID
NCT05300971
Status
Recruiting
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Conditions

  • Aging

Eligibility Criteria

Sex
ALL
Age
40 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Heat therapy — OTHER
    36 sessions (\~3x per week for 12 weeks) of hot water immersion in 40°C water, sufficient to raise body core temperature to 38.5°C, and 12 weeks of follow-up.
  • Thermoneutral water immersion — OTHER
    36 sessions (\~3x per week for 12 weeks) of thermoneutral water immersion in 36°C water to prevent changes in body core temperature \>0.2°C, and 12 weeks of follow-up.

Study Details

This study aims to determine the effects of \~12 weeks of repeated hot water immersion ("heat therapy") vs. thermoneutral water immersion on blood pressure and vascular function in late middle-life to older (≥40 years) adults. The study also aims to determine the effects of \~12 weeks of heat therapy on fluid cognitive and cerebrovascular function.

Key Dates

Start date
Aug 1, 2022
Status verified
Apr 2025
Primary completion
Nov 1, 2027
Completion
Feb 1, 2028

Study Design

Enrollment
150 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Heat therapy
    Hot water immersion \~3x per week for 12 weeks
  • Sham Comparator: Thermoneutral water immersion
    Thermoneutral water immersion \~3x per week for 12 weeks

Primary Outcome Measure

Change in casual systolic blood pressure from baseline to 2, 4, 6, 8, 10, and 12 weeks of heat therapy, and 4 and 12 weeks of follow-up. [ Time Frame: 0 weeks, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks, 12 weeks, 16 weeks, 24 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Colorado BoulderBoulderColorado80309
Vienna E Brunt, PhD
[email protected]
303-735-4554

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By research site
University of Colorado Boulder· Boulder, CO

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