Mode of Exercise and Bone Biomarkers in Older Veterans

Part of paid clinical trials in Aurora, Colorado.

Sponsor
VA Office of Research and Development
Study ID
NCT05266976
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
60 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • 10 Weeks of Supervised Resistance Exercise Training — BEHAVIORAL
    Participants will be randomized to complete 10 weeks of either resistance (weight lifting, hopping) supervised exercise. Exercise will be 3x per week for 1 hour each session. There are a total of 30 exercise sessions.
  • 10 Weeks of Supervised Endurance Exercise Training — BEHAVIORAL
    Participants will be randomized to complete 10 weeks of endurance (stationary cycling) supervised exercise. Exercise will be 3x per week for 1 hour each session. There are a total of 30 exercise sessions.

Study Details

Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences blood markers of bone resorption for either endurance or resistance exercise. The purpose of this study is to determine 1) if resistance exercise causes a similar increase in bone resorption as endurance exercise; and 2) if exercise training influences the increase in bone resorption following exercise for both endurance and resistance exercise.

Key Dates

Start date
Jul 6, 2022
Status verified
May 2026
Primary completion
Mar 31, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Resistance Exercise
    Participants will perform total body resistance training 3x per week for 10 weeks. Each exercise session will last approximately 1 hour.
  • Experimental: Endurance Exercise
    Participants will complete 60 minutes of stationary cycling 3x per week at 70-80% of maximal heart rate for 10 weeks.

Primary Outcome Measure

c-telopeptide of type 1 collagen (CTX) change [ Time Frame: Before exercise to up to 48 hours after each exercise bout ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Rocky Mountain Regional VA Medical Center, Aurora, COAuroraColorado80045-7211
Todd R Furbacher, PhD
[email protected]
720-857-5105
Kimberly K Owens, MPH
[email protected]
(720) 857-5667
Sarah J Wherry, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Rocky Mountain Regional VA Medical Center, Aurora, CO· Aurora, CO

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