Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations

Part of paid clinical trials in Brockton, Massachusetts.

Sponsor
Boston VA Research Institute, Inc.
Study ID
NCT05299749
Status
Recruiting
Apply to this trial

Conditions

  • Auditory Hallucination
  • Schizophrenia
  • Treatment-resistant Schizophrenia

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Not accepted

Interventions

  • stg-rt-fMRI-Neurofeeback — OTHER
    the patients will receive real-time feedback from the brain activity of the superior temporal gyrus
  • sham-rt-fMRI-Neurofeedback — OTHER
    the patients will receive real-time feedback from the brain activity of the somato-motor cortex

Study Details

Neurofeedback intervention aimed to regulate the superior temporal gyrus (STG) activation and default mode network (DMN) connectivity as well as to reduce the auditory hallucinations (AH) schizophrenia patients with medication resistant AH.

Key Dates

Start date
Mar 1, 2022
Status verified
Sep 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
104 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: stg-rt-fMRI
    will receive feedback from the STG
  • Sham Comparator: sham-rt-fMRI
    will receive feedback from the motor cortex

Primary Outcome Measure

percent change in the STG BOLD signal, post- relative to pre-NFB [ Time Frame: 0-4 weeks post intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Boston VA Healthcare System, BrocktonBrocktonMassachusetts02301
Mia Kriksciun, BA
[email protected]
774 826 1507

Find similar trials in Brockton, MA

By condition
Schizophrenia
By specialty
PsychiatryMental healthBehavioral health
By research site
Boston VA Healthcare System, Brockton· Brockton, MA

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