Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness

Part of paid clinical trials in Charlestown, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT04940663
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • EMA — BEHAVIORAL
    Participants will complete surveys about their feelings and social habits through a smartphone app (EMA)

Study Details

The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in early detection efforts.

Key Dates

Start date
Jul 13, 2022
Status verified
May 2026
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
120 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Other: Ecological Momentary Assessment
    EMA collected daily (4x/day) for two weeks

Primary Outcome Measure

Trait level social isolation and loneliness [ Time Frame: 6 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Massachusetts General HospitalCharlestownMassachusetts02129
Daphne J Holt, MD, PhD
[email protected]
617-726-7618
Nicole DeTore, PhD
[email protected]
617-726-2065

Find similar trials in Charlestown, MA

By condition
Schizophrenia
By specialty
PsychiatryMental healthBehavioral health
By research site
Massachusetts General Hospital· Charlestown, MA

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