The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD Adults

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Boston Children's Hospital
Study ID
NCT05258981
Status
Recruiting
Apply to this trial

Conditions

  • Congenital Heart Disease

Eligibility Criteria

Sex
ALL
Age
24 Years - 35 Years
Healthy Volunteers
Accepted

Interventions

  • MRI — DIAGNOSTIC_TEST
    Brain MRI

Study Details

The main purpose of this proposal is to perform novel MRI analyses to determine the brain organizational changes associated with altered executive function and the modulating role of variants in neuroresilience and hypoxia response genes in adults with d-transposition of the great arteries (d-TGA).

Key Dates

Start date
Jul 1, 2022
Status verified
Aug 2023
Primary completion
Jan 31, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
225 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Other: Brain MRI
    Obtain Brain MRI in adults with congenital heart disease and age/sex matched controls

Primary Outcome Measure

Delis-Kaplan Executive Function Scale (D-KEFS) composite score; [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Boston Children's HospitalBostonMassachusetts02115
Michelle Gurvitz, MD
[email protected]
617-355-6508
Donna Duva
[email protected]
617-355-5422

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By research site
Boston Children's Hospital· Boston, MA

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