MRI in High-Grade Glioma Patients Undergoing Chemoradiation

Part of paid clinical trials in Winston-Salem, North Carolina.

Sponsor
Wake Forest University Health Sciences
Study ID
NCT05212272
Status
Recruiting
Apply to this trial

Conditions

  • High Grade Glioma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • PET-MRI Brain Scan — PROCEDURE
    Before starting radiation, participants will have a PET scan and MRI scan of the brain. After 2 to 3 weeks of radiation treatments, participants will have a repeat PET scan. Then 1 month after radiation participants will have another PET scan
  • Blood draw — DIAGNOSTIC_TEST
    Blood draws will be taken at baseline, one month after radiation treatment and 3 to 4 months after radiation treatment.
  • Memory testing — BEHAVIORAL
    3 sessions with simple tests to evaluate how the brain is working. These tests primarily check things like memory, attention, and thought process. The whole set of tests will take 1 hour each time.
  • Optional lumbar puncture for cerebrospinal fluid collection — PROCEDURE
    Participants that consent for cerebrospinal fluid collection will have 6 and 20 ml of cerebrospinal collected at baseline.

Study Details

The purpose of this research study is to see if investigators can predict how brain functioning changes after radiation treatment based on PET scans and blood tests. Most participants experience at least mild decreases in their memory or attention after radiation therapy. Investigators hope that PET scans, lumbar puncture, and blood tests might help investigators predict who might have larger changes in their brain function after radiation.

Key Dates

Start date
Sep 2, 2022
Status verified
Mar 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
16 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: PET-MRI In High-Grade Glioma Patients Undergoing Chemoradiation
    PET scan and MRI scan of the brain, blood draw, and 1-hour of memory testing.

Primary Outcome Measure

Number of Participants to Complete Two PET scans [ Time Frame: At baseline and at 4 months post-treatment ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Wake Forest Baptist Comprehensive Cancer CenterWinston-SalemNorth Carolina27157
Study Coordinator
[email protected]
336-716-0892
Study Nurse
[email protected]
336-713-3539
Christina Cramer, MD (PRINCIPAL_INVESTIGATOR)

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By research site
Wake Forest Baptist Comprehensive Cancer Center· Winston-Salem, NC

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