Neural Bases of Vocal Sensorimotor Impairment in Aphasia

Part of paid clinical trials in Irvine, California.

Sponsor
The University of Texas at Dallas
Study ID
NCT04742894
Status
Recruiting
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Conditions

  • Aphasia

Eligibility Criteria

Sex
ALL
Age
21 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • Visual Feedback Training — BEHAVIORAL
    Participants will be trained to work with a computer setup to control the position of a visual cursor on the screen using their speech while their auditory feedback is altered. The goal of the training is to help improve speech production and motor control ability.

Study Details

Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control. While recovery can be promoted with speech therapy, improvement remains modest and typically requires a large number of sessions contributing to rising health care costs. Traditional aphasia therapy focus on enhancing speech motor output; however, recent evidence suggests that the auditory feedback also plays a critical role in fluent speech. Therefore, a key step toward refining treatment strategies is to develop objective biomarkers that can probe the integrity of sensorimotor mechanisms of speech auditory feedback and identify their impaired function in patients with post-stroke aphasia. This study aims to examine the behavioral, neurophysiological (EEG), and neuroimaging (fMRI) biomarkers of speech impairment following stroke with focus on understanding the role of auditory feedback for speech production and control. We plan to test individuals with post-stroke aphasia and a matched neuroptypical control group during different speech production tasks under the altered auditory feedback paradigm. In addition, we aim to examine the effect of audio-visual feedback training on enhancing communication ability during speech. These biomarkers will be combined with existing lesion-symptom-mapping data in the aphasic group in order to identify the patterns of brain damage and diminished structural connectivity within the auditory-motor areas of the left hemisphere that predict impaired sensorimotor processing of speech in aphasia. The long-term goal of this research is to develop a model for identifying the source of sensorimotor deficit and improve diagnosis and targeted treatment of speech disorders in aphasia.

Key Dates

Start date
Jul 11, 2021
Status verified
Jun 2025
Primary completion
Feb 28, 2027
Completion
Feb 28, 2027

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Aphasia Group
  • Experimental: Control Group

Primary Outcome Measure

Speech Production and Motor Control Ability [ Time Frame: 2 weeks ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
University of California IrvineIrvineCalifornia92697
Gregory Hickok, PhD
[email protected]
949-824-1409
University of South CarolinaColumbiaSouth Carolina29208
Julius Fridriksson, PhD
[email protected]
803-777-5931
Christopher Rorden, PhD (SUB_INVESTIGATOR)
Leonardo Bonilha, MD (SUB_INVESTIGATOR)
The University of Texas at DallasRichardsonTexas75080
Roozbeh Behroozmand, PhD
[email protected]
972-883-3062

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By research site
University of California Irvine· Irvine, CAUniversity of South Carolina· Columbia, SCThe University of Texas at Dallas· Richardson, TX

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