Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding

Part of paid clinical trials in Baton Rouge, Louisiana.

Sponsor
Pennington Biomedical Research Center
Study ID
NCT04583514
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 42 Years
Healthy Volunteers
Accepted

Interventions

  • Control — BEHAVIORAL
    Weight-stable Control group
  • Overfeeding — BEHAVIORAL
    30% Overfeeding group

Study Details

Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans. The capacity of subcutaneous (subQ) adipose tissue to expand and remodel is an important determinant of obesity-related health complications, and impaired expansion of subQ fat tissue is thought to contribute to the risk of diseases such as the Metabolic Syndrome (MetS) and type 2 diabetes mellitus (T2D). The objectives of the study are to evaluate the changes and mechanisms of (subQ) adipose tissue expandability that occur as a result of short-term weight gain and to investigate the effects on cardio-metabolic health outcomes. Findings from this study will provide new insight into the dynamics of adipose expansion and remodeling during changes in energy balance and how this may impact future fat tissue function and metabolic health.

Key Dates

Start date
Sep 15, 2020
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
58 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: Control
    The control group will be expected to maintain their weight within 1 kg of baseline weight throughout the duration of the study.
  • Experimental: Overfeeding
    The overfeeding group will be subjected to a similar relative change in energy intake, in which their dietary intake will be 30% more kcal/d than needed for weight maintenance.

Primary Outcome Measure

Adipose tissue expansion and remodeling -- in vivo adipocyte formation [ Time Frame: 8 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Pennington Biomedical Research CenterBaton RougeLouisiana70809
Ursula White, Ph.D.
[email protected]
225-763-2656

Find similar trials in Baton Rouge, LA

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Pennington Biomedical Research Center· Baton Rouge, LA

Related Studies