Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome

Part of paid clinical trials in Charlottesville, Virginia.

Sponsor
University of Virginia
Study ID
NCT04575844
Phase
PHASE4
Status
Recruiting
Apply to this trial

Conditions

  • Metabolic Syndrome

Eligibility Criteria

Sex
ALL
Age
21 Years - 60 Years
Healthy Volunteers
Accepted

Interventions

Study Details

The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and skeletal muscle microvascular blood volume, improves vascular function of the conduit vessels, and enhances insulin's metabolic action in humans with Metabolic Syndrome. Subjects will be randomized to one of the 4 groups: control, exercise training, liraglutide treatment, and exercise + liraglutide. They will be studied at the baseline and then after 24 weeks of intervention.

Key Dates

Start date
Nov 1, 2020
Status verified
May 2026
Primary completion
Apr 30, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Exercise Alone
    24 weeks of treatment
  • Experimental: Liraglutide Alone
    24 weeks of treatment
  • Experimental: Exercise + Liraglutide
    24 weeks f treatment

Primary Outcome Measure

Microvascular Blood Volume - change from baseline [ Time Frame: 24 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of VirginiaCharlottesvilleVirginia22906
Zhenqi Liu, MD
[email protected]
434-243-2603
Eugene Barrett, MD, PhD
[email protected]
434-924-1175

Find similar trials in Charlottesville, VA

By research site
University of Virginia· Charlottesville, VA

Related Studies