Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
University of Alabama at Birmingham
Study ID
NCT04396002
Status
Recruiting
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Conditions

  • Primary Open Angle Glaucoma

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Accepted

Interventions

  • Life Space Questionnaire — DIAGNOSTIC_TEST
    This 9-item questionnaire is interested in finding out how much a person gets out and about and the spatial extent of the person's typical life space, i.e., what is the usual range of places in which the person engages in activities within the designated time frame.
  • Low Luminance Questionnaire — DIAGNOSTIC_TEST
    This 32-item questionnaire is interested in finding out problems that involve vision under different lighting conditions or feelings that people have about your vision under different lighting conditions.
  • Contrast sensitivity under dim illumination — DIAGNOSTIC_TEST
    Participants will be presented with visual targets of different contrast under dim illumination and asked to report when they see the target.
  • Visual field under dim illumination (MAIA) — DIAGNOSTIC_TEST
    Sensitivity in the central visual area will be assessed under dim illumination
  • Macular Pigment Optical Density (MPOD) — DIAGNOSTIC_TEST
    Participants will be asked to look at a fixation target and the density of their macular pigment will be assessed.
  • Dark Adaptation — DIAGNOSTIC_TEST
    After adapting to a dark environment, participants will be exposed a bright flask of light. the time needed for them to recover their sensitivity will be measured.

Study Details

Mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on the other extreme. Primary open-angle glaucoma (POAG) is a chronic, progressive optic neuropathy that can lead to gradual loss of vision in the peripheral field and central vision. Older adults with POAG have an increased risk for motor vehicle collisions and falls. Moreover, existing studies suggest that patients with POAG exhibit more postural sway while standing as measured by a balance platform and also tend to walk more slowly than those who are normally sighted and free of ocular disease. While these disturbances likely influence mobility, there has been little research directly assessing the impact of POAG on mobility. This study will assess the impact of POAG on life space (one aspect of mobility) and will determine whether difficulties with life space are associated with difficulties experienced under conditions of dim lighting.

Key Dates

Start date
Jun 1, 2019
Status verified
Sep 2025
Primary completion
May 30, 2026
Completion
May 30, 2026

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Primary Open-Angle Glaucoma
    Patients diagnosed with primary open-angle glaucoma.
  • Arm: Control
    Participants with healthy eyes.

Primary Outcome Measure

Assessment of life space measured with the Life Space Questionnaire [ Time Frame: Through study completion, an average of 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Alabama BirminghamBirminghamAlabama35294-0001
Lyne Racette, PhD
[email protected]
2053258673
Lyne Racette, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Alabama Birmingham· Birmingham, AL

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