Diagnostic Innovations in Glaucoma Study

Conditions

• Myopia
• Primary Open Angle Glaucoma

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Study Details

The overarching goal of our research study is to evaluate changes in visual function and optic nerve topography (the structure of the back of the eye) in patients with glaucoma (increased susceptibility to pressure inside the eye that can cause loss of vision) or those with an increased risk of developing the disease. The purpose of this study is to determine the best methods for detecting the presence or progression (worsening over time) of glaucoma in patients with and without myopia and its effects on daily and visual function and quality of life. With several sources of NIH and foundation funding over the last twenty years we have designed a robust research protocol to address the most challenging aspects of glaucoma management. The most recent focus of this research is 1) to improve our ability to detect open angle glaucoma in individuals with myopia and in individuals of European and African descent, 2) to determine whether monitoring of the retinal vasculature with new optical imaging instruments can improve glaucoma management and elucidate the pathophysiology of the disease, and 3) to differentiate between age-related changes and glaucomatous progression. The grants supporting this project include 3 NIH funded studies, 1) the University of California, San Diego UCSD -based "Diagnostic Innovations in Glaucoma Study" (DIGS funded since 1995): 2) the "African Descent and Glaucoma Evaluation Study" (ADAGES funded since 2002), 3) the Brightfocus Foundation National Glaucoma Research Program and 4) the UCSD-based "Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography Angiography" (funded since 2018). The ADAGES is a multi-center study with data collection also conducted at 2 other academic sites, the University of Alabama at Birmingham, and Columbia University. Enrolled healthy participants, glaucoma suspects and glaucoma patients are generally asked to return for two or more visits a year for several years. We then analyze whether the glaucoma patients are progressing and what factors influence their glaucoma status compared to healthy subjects and individuals suspected of having glaucoma.

Key Dates

Start date

Apr 30, 1995

Status verified

Oct 2025

Primary completion

Jul 31, 2030

Completion

Jul 31, 2030

Study Design

Enrollment

3,000 participants (estimated)

Arms

• Arm: Healthy individuals
  healthy controls with or without myopia
• Arm: Persons at risk for or with primary open angle glaucoma
  with or without myopia with a diagnosis of glaucoma, glaucoma suspect and ocular hypertension

Central Contacts

• Veronica Inpirom
  858-822-4669
  [email protected]

Locations (1)

Find similar trials in La Jolla, CA

Related Studies

• Hydrus® Microstent New Enrollment Post-Approval Study
  Recruiting · Alcon Research · Irvine, California
• MiSight 1 Day Safety Post-Approval Study
  Recruiting · CooperVision, Inc. · Gilbert, Arizona
• MiSight 1 Day Post-Approval Study for Effectiveness and Visual Symptoms
  Recruiting · CooperVision, Inc. · Birmingham, Alabama
• Efficacy of Repeated Low-level Red-light Therapy in Myopia Control
  Recruiting · University of California, San Francisco · San Francisco, California