DNA Repair Activity in the Skin of Day and Night Shift Workers

Part of paid clinical trials in Fairborn, Ohio.

Sponsor
Wright State University
Study ID
NCT04122456
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Ultraviolet B Radiation — RADIATION
    One skin punch biopsy will be taken to the laboratory for exposure to ultraviolet B radiation. After 1-hour incubation, the biopsies will be bisected in half.
  • No Ultraviolet B Radiation — OTHER
    One skin punch biopsy will be taken to the laboratory and will be kept as a non-irradiated control.

Study Details

The purpose of this study is to test how the skin of night shift workers responds to artificial sunlight (ultraviolet B radiation; UVB) at two different times of the day in comparison to normal day shift workers. After the skin biopsies are obtained, they will be brought to the laboratory to be exposed to UVB radiation and to measure UVB responses.

Key Dates

Start date
Dec 7, 2022
Status verified
Feb 2025
Primary completion
Dec 31, 2025
Completion
Dec 31, 2025

Study Design

Enrollment
48 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Day Shift Work Schedule
    Day shift worker skin biopsies will be exposed to artificial sunlight (ultraviolet B radiation; UVB) at the laboratory.
  • Experimental: Night Shift Work Schedule
    Night shift worker skin biopsies will be exposed to artificial sunlight (ultraviolet B radiation; UVB) at the laboratory.

Primary Outcome Measure

Expression level of the DNA repair factor XPA at two times of the day in the skin of day and night shift workers. [ Time Frame: After 1 hour incubation from ultraviolet B radiation exposure. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Wright State PhysiciansFairbornOhio45324
Pharmacology Translational Unit
937-245-7500

Find similar trials in Fairborn, OH

By condition
Skin cancer
By specialty
OncologySkin cancerDermatology
By research site
Wright State Physicians· Fairborn, OH

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