Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
National Institute on Drug Abuse (NIDA)
Study ID
NCT03745339
Status
Recruiting
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Conditions

  • Drug Addiction
  • Opioid-Related Disorders

Eligibility Criteria

Sex
ALL
Age
21 Years - 60 Years
Healthy Volunteers
Accepted

Study Details

Background: People with addictions often find it hard to choose the long-term benefits of abstinence over the short-term effects of using drugs. Researchers think this is partly due to parts of the brain involved in certain types of learning and decision-making. Researchers want to test these basic functions using a simple task with pictures and odors. Objective: To see if performance in a learning task differs between people who have opioid-use disorder and people who don t. Eligibility: Adults 21-60 years old who are willing to fast for at least 6 hours and smell food odors. Those with an opioid-use disorder must either not use for at least 3 weeks or be in treatment. Design: Participants will have 1 visit that will take up to 5 hours. Before the visit, participants will be asked to not eat or drink anything except water for at least 6 hours. At the visit, participants will be checked for signs of intoxication. Participants will give urine and breath samples. Participants will have tests of learning and behavior. They will look at shapes on a computer screen. The shapes will be paired with different food odors. The odors will come from a sterile tube placed under the nose. Participants will have their breathing monitored with a belt around the upper abdomen. About 30 days and 60 days later, participants will be called and asked about their drug use over the past 30 days.

Key Dates

Start date
Jun 7, 2019
Status verified
Apr 2026
Primary completion
Oct 1, 2026
Completion
Oct 1, 2026

Study Design

Enrollment
150 participants (estimated)

Arms

  • Arm: Abstinent OUD
    Men and women with history of OUD, but abstinent for at least 3 weeks and not in agonist treatment
  • Arm: Controls
    Men and women with no history of a substance-use disorder (except nicotine, for matching purposes) and not using any drug for nonmedical purposes
  • Arm: In-treatment OUD
    Men and women with opioid use disorder (OUD) being treated with an agonist (buprenorphine or methadone)

Primary Outcome Measure

Outcome inferencing in the probe test [ Time Frame: During task ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institute on Drug AbuseBaltimoreMaryland21224
Shannon Pfistner
[email protected]
800-535-8254

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By research site
National Institute on Drug Abuse· Baltimore, MD

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