Neurocognitive Mechanisms Underlying Smartphone-Assisted Prevention of Relapse in Opioid Use Disorder

Part of paid clinical trials in Little Rock, Arkansas.

Sponsor
University of Arkansas
Study ID
NCT05336188
Status
Enrolling By Invitation

Conditions

  • Attentional Bias
  • Craving
  • Ecological Momentary Assessment
  • Magnetic Resonance Imaging
  • Mobile Applications
  • Opiate Substitution Treatment
  • Opioid-Related Disorders

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Smartphone — DEVICE
    Adjunctive Smartphone app for improving MAT outcomes

Study Details

The proposed clinical trial would evaluate the use of smartphone applications ("apps", which have well-established efficacy in reducing cigarette and alcohol use) to prevent relapse among patients receiving medication-assisted treatment for opioid use disorder. In addition to standard app-based self-monitoring of drug use and personalized feedback, project innovation is enhanced by the proposed use of location-tracking technology for targeted, personalized intervention when participants enter self-identified areas of high risk for relapse. Furthermore, the proposed sub-study would use longitudinal functional neuroimaging to elucidate the brain-cognition relationships underlying individual differences in treatment outcomes, offering broad significance for understanding and enhancing the efficacy of this and other app-based interventions.

Key Dates

Start date
May 16, 2023
Status verified
Apr 2026
Primary completion
Sep 30, 2027
Completion
Sep 30, 2028

Study Design

Enrollment
336 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Smartphone
    Participants randomized into the Smartphone app arm would use the smartphone app OptiMAT in conjunction with treatment as usual (TAU). Participants would use OptiMAT to complete daily self-assessments of opiate misuse, opiate craving, opiate withdrawal, and mood. The app will personalized feedback for maintaining abstinence goals. The app would also use geographic ecological momentary assessment (GEMA) to intervene via push notification when participants enter areas previously identified as high-risk for opiate use.
  • No Intervention: Monitoring Only
    Participants randomized into the Monitoring Only arm would undergo treatment as usual (TAU) but without the smartphone app.

Primary Outcome Measure

Urinalysis - Week 0 (Intake) [ Time Frame: 1 day ]

Locations (1)

FacilityCityStateZIPSite coordinators
Brain Imaging Research CenterLittle RockArkansas72227-

Find similar trials in Little Rock, AR

By research site
Brain Imaging Research Center· Little Rock, AR

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