Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow

Conditions

• Colorectal Cancer
• Esophageal Cancer
• Gastric Cancer
• Hepatocellular Cancer
• Non Small Cell Lung Cancer
• Pancreatic Cancer

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Test for circulating tumor cells, DNA alterations — DIAGNOSTIC_TEST

Study Details

Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery. Also, early detection of lung cancer with low dose CT screening may cure patients at an early stage. Circulating and disseminated tumor cell (CTC/DTC) and circulating cell-free (cf) DNA isolation from the blood, urine and bone marrow will increase understanding of cancer spread and advance knowledge to develop individualized therapies and improve screening.

Key Dates

Start date

Jul 1, 2016

Status verified

Oct 2025

Primary completion

Dec 30, 2027

Completion

Dec 30, 2027

Study Design

Enrollment

320 participants (estimated)

Arms

• Arm: Patients having surgery
  Cancer patients undergoing surgery will have test for circulating tumor cells, DNA alterations
• Arm: Patients not having surgery
  Cancer patients not undergoing surgery (but potentially other treatments) will have test for circulating tumor cells, DNA alterations. Lung cancer screening subjects
• Arm: Healthy subjects
  Healthy control subjects will have test for circulating tumor cells, DNA alterations

Primary Outcome Measure

Number of CTC/DTC in blood [ Time Frame: At baseline ]

Central Contacts

• Jussuf T Kaifi, MD
  5738146565
  [email protected]
• Jussuf T Kaifi, MD
  5738146565
  [email protected]

Locations (1)

Find similar trials in Columbia, MO

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