Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Study ID
NCT03510442
Status
Recruiting
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Conditions

  • Arthritis
  • Autoinflammatory Syndrome
  • Still's Disease, Adult-Onset
  • Systemic Inflammation

Eligibility Criteria

Sex
ALL
Age
1 Day - 100 Years
Healthy Volunteers
Accepted

Study Details

Background: Inflammatory conditions can cause symptoms like fevers, arthritis, and rash. Systemic juvenile idiopathic arthritis (sJIA) is one of these conditions. So is adult-onset Still s disease (AOSD). Their causes are unknown. Researchers want to learn more about these conditions. This includes genetic changes and environmental factors. Objective: To study sJIA and AOSD in children and adults over time. Eligibility: People with known or suspected sJIA, AOSD, or similar inflammatory condition Design: Participants will be screened with a phone call. Participants will have 1 visit. It may be outpatient or they may be admitted to the clinic. The visit may last up to 5 days. Participants will have: * Medical history * Physical exam * Musculoskeletal exam * Questions about overall health and quality of life, disease activity, functional status, and cognitive ability. Participants may also have: * Pictures taken of their skin, joints, or spine * Blood, urine, and stool tests * Scans or X-rays of joints with arthritis * Chest X-ray * Heart tests * Skin biopsy. The skin will be numbed. The top layers of a small area will be scraped off. Participants who have a joint aspiration may provide a fluid sample. The joint will be prepared, then fluid is removed by needle. A corticosteroid may be injected. Participants who have a bone marrow biopsy may provide sample cells. Participants may be seen by NIH specialists. Members of the participant s family and healthy volunteers may give blood or saliva samples for genetic testing. Participants may repeat some study tests every 6 months.

Key Dates

Start date
May 21, 2018
Status verified
Apr 2026
Primary completion
Jan 1, 2050
Completion
Jan 1, 2050

Study Design

Enrollment
2,000 participants (estimated)

Arms

  • Arm: adult-onset Still's disease (AOSD)
    Composed of patients with known or suspected AOSD as defined by Yamaguchi criteria.
  • Arm: family members
    Composed of family members of patients with systemic juvenile idiopathic arthritis, adult-onset Still's disease and related conditions.
  • Arm: healthy volunteers
    Composed of healthy adults and children (above the age of 6 years) who volunteer to participate in this protocol.
  • Arm: related inflammatory conditions
    Composed of patients with suspected inflammatory disease as indicated by the presence of episodic fever and/ or arthritis.
  • Arm: systemic juvenile idiopathic arthritis (sJIA)
    Composed of patients with known or suspected sJIA as defined by the international league of Associations for Rheumatology (ILAR) criteria

Primary Outcome Measure

Genetic sequencing of patients [ Time Frame: Ongoing ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892
For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)
[email protected]
800-411-1222

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By research site
National Institutes of Health Clinical Center· Bethesda, MD

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