Natural History and Development of Spondyloarthritis

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Study ID
NCT01422694
Status
Recruiting
Apply to this trial

Conditions

  • Arthritis
  • Spondylitis, Ankylosing

Eligibility Criteria

Sex
ALL
Age
2 Years - 99 Years
Healthy Volunteers
Accepted

Study Details

Background: \- Spondyloarthritis (SpA) is a group of bone and joint disorders that may cause back and joint pain and stiffness. In some cases, SpA can lead to abnormal bone growth affecting the joints and spine. Some patients have SpA without ever developing these growths, while others develop them after only a few years. Researchers are interested in studying people with SpA and their relatives to determine which people are more likely to develop more severe conditions. Objectives: \- To identify symptoms and medical tests that can help determine whether a person with SpA is at risk for developing more severe forms of the disease. Eligibility: * Individuals of any age who have been diagnosed with SpA. * Healthy volunteer relatives (at least 6 years of age) of the individuals with SpA. Design: * Participants will be screened with medical records and family medical histories, and will be invited to the clinical center for the study. * Participants with SpA will have a physical exam and medical history, including a study of joint movement, blood and urine tests, and questionnaires about pain and quality of life. * Participants with SpA will have imaging studies, including magnetic resonance imaging (MRI). Other samples such as skin tissue and bone marrow may also be collected for study. * Healthy volunteers will provide a blood sample and cheek cell samples. * No treatment will be provided, although treatment options will be discussed....

Key Dates

Start date
Aug 12, 2011
Status verified
May 2026

Study Design

Enrollment
2,000 participants (estimated)

Arms

  • Arm: Healthy control
    Healthy volunteers will be recruited to serve as controls
  • Arm: Other Inflammatory Diseases
    Subjects with Other Inflammatory Diseases
  • Arm: Patients with Spondyloarthritis
    Subjects with confirmed or probable SpA will be identified predominantly by physician referral.

Primary Outcome Measure

Progression from SpA to Axial Spa and to AS [ Time Frame: 10 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892-

Find similar trials in Bethesda, MD

By research site
National Institutes of Health Clinical Center· Bethesda, MD

Related Studies