Long-term Follow-up Study of Patients Receiving CAR-T Cells

Part of paid clinical trials in Milwaukee, Wisconsin.

Sponsor
Medical College of Wisconsin
Study ID
NCT03375619
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Long-Term Follow-Up of Participants who Received CAR-T cells — OTHER
    No study drug is administered in this study. Participants who received CAR-T cells in a previous trial will be evaluated in this trial for long-term safety and efficacy.

Study Details

This protocol is designed as a long-term follow-up study of participants who will receive CAR-T cells as part of a clinical trial at the Medical College of Wisconsin/ Froedtert Hospital. The clinical trials include the following: Phase 1 Study of CAR-20/19-T Cells in Patients with Relapsed Refractory B Cell Malignancies (NCT03019055); Phase I Trial of BCMA-TGF-BETA CAR-T Cells in Relapsed, Refractory Myeloma (NCT05976555); CAR20.19.22 T-cells in Relapsed, Refractory B-cell Malignancies (NCT05094206); LV20.19 CAR T-Cells in Combination With Pirtobrutinib for Relapsed, Refractory B-cell Malignancies (NCT05990465); CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies (NCT04186520)

Key Dates

Start date
Dec 1, 2017
Status verified
Nov 2025
Primary completion
Jan 1, 2035
Completion
Jan 1, 2035

Study Design

Enrollment
500 participants (estimated)

Arms

  • Arm: Participants who received CAR-T cells.
    Participants who received CAR-T cells at Froedtert Hospital \& the Medical College of Wisconsin in clinical trials (e.g., NCT05976555, NCT05094206, NCT05990465, NCT03019055 or NCT04186520).

Primary Outcome Measure

Change from baseline in the incidence of a new malignancy at 5 years. [ Time Frame: Baseline to five years. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Froedtert Hospital & Medical College of WisconsinMilwaukeeWisconsin53226
Cancer Center Clinical Trials Office
[email protected]
414-805-8900

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Froedtert Hospital & Medical College of Wisconsin· Milwaukee, WI

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