Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration

Part of paid clinical trials in Cincinnati, Ohio.

Sponsor
Children's Hospital Medical Center, Cincinnati
Study ID
NCT02316379
Phase
PHASE1/PHASE2
Status
Recruiting
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Conditions

  • Respiratory Disorders

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Hyperpolarized 129 Xenon — DRUG
    During the scans, subject will inhale hyperpolarized Xenon gas for up to 16 seconds per scan, for up to 4 separate MR scans
  • MRI — DEVICE

Study Details

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of adults for the purposes of obtaining optimal images through MRI.

Key Dates

Start date
Feb 28, 2015
Status verified
Apr 2024
Primary completion
Aug 24, 2030
Completion
Aug 24, 2031

Study Design

Enrollment
100 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Hyperpolarized 129 Xenon
    Administration of up to 1 liter doses of Hyperpolarized Xenon gas during MRI to optimize acquisition of images for adults vs. proton MR imaging. These scans, utilizing volunteers for calibration, may be utilized through this study to optimize the scan details.

Primary Outcome Measure

Correlation of ventilated volume predictions obtained with 129Xe MRI vs. 1H MRI [ Time Frame: Day 1 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Cincinnati Children's Hospital Medical CenterCincinnatiOhio45229
Jason C Woods, Ph.D
[email protected]
513-803-4463

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Cincinnati Children's Hospital Medical Center· Cincinnati, OH

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