Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults

Part of paid clinical trials in Cincinnati, Ohio.

Sponsor
Children's Hospital Medical Center, Cincinnati
Study ID
NCT02272049
Phase
PHASE1/PHASE2
Status
Recruiting
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Conditions

  • Respiratory Disorders

Eligibility Criteria

Sex
ALL
Age
6 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Hyperpolarized 129 Xenon — DRUG
    During the scans, subject will inhale hyperpolarized Xenon gas for up to 16 seconds per scan, for up to 4 separate MR scans

Study Details

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.

Key Dates

Start date
Dec 31, 2014
Status verified
Feb 2026
Primary completion
Dec 31, 2028
Completion
Aug 31, 2029

Study Design

Enrollment
300 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Hyperpolarized 129 Xenon
    Administration of up to 1 liter doses of Hyperpolarized Xenon gas during MRI (less for children) to optimize acquisition of images for children and adults vs. proton MR imaging

Primary Outcome Measure

Correlation of ventilated volume predictions obtained with 129Xe MRI vs. 1H MRI [ Time Frame: Day 1 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Cincinnati Children's Hospital Medical CenterCincinnatiOhio45229
Jason C. Woods, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Cincinnati Children's Hospital Medical Center· Cincinnati, OH

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