Chemotherapy With or Without Biological Therapy in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy

Part of paid clinical trials in Denver, Colorado.

Sponsor
Eastern Cooperative Oncology Group
Study ID
NCT00005847
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
MALE
Age
18 Years - 120 Years
Healthy Volunteers
Not accepted

Interventions

  • recombinant interferon alfa — BIOLOGICAL
  • estramustine phosphate sodium — DRUG
  • isotretinoin — DRUG
  • mitoxantrone hydrochloride — DRUG
  • paclitaxel — DRUG
  • vinorelbine ditartrate — DRUG

Study Details

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. It is not yet known which treatment regimen is more effective in treating metastatic prostate cancer. PURPOSE: Randomized phase II trial to compare the effectiveness of combination chemotherapy with that of chemotherapy plus biological therapy in treating patients who have progressive or metastatic prostate cancer that has not responded to hormone therapy.

Key Dates

Start date
Apr 5, 2001
Status verified
Jun 2023
Primary completion
Jul 31, 2004

Study Design

Allocation
RANDOMIZED
Primary purpose
TREATMENT

Locations (19)

FacilityCityStateZIPSite coordinators
CCOP - Colorado Cancer Research Program, IncorporatedDenverColorado80224-
Emory University Hospital - AtlantaAtlantaGeorgia30322-
Veterans Affairs Medical Center - Atlanta (Decatur)DecaturGeorgia30033-
CCOP - Carle Cancer CenterUrbanaIllinois61801-
Tufts - New England Medical CenterBostonMassachusetts02111-
CCOP - KalamazooKalamazooMichigan49007-3731-
Mayo Clinic Cancer CenterRochesterMinnesota55905-
CCOP - Metro-MinnesotaSaint Louis ParkMinnesota55416-
CCOP - Northern New JerseyHackensackNew Jersey07601-
Cancer Institute of New JerseyNew BrunswickNew Jersey08903-
MBCCOP-Our Lady of Mercy Cancer CenterThe BronxNew York10466-
CCOP - Merit Care HospitalFargoNorth Dakota58122-
Ireland Cancer CenterClevelandOhio44106-5065-
CCOP - Toledo Community HospitalToledoOhio43623-3456-
CCOP - Geisinger Clinic and Medical CenterDanvillePennsylvania17822-2001-
Fox Chase Cancer CenterPhiladelphiaPennsylvania19111-
CCOP - Sioux Community Cancer ConsortiumSioux FallsSouth Dakota57104-
CCOP - St. Vincent Hospital Cancer Center, Green BayGreen BayWisconsin54307-3453-
Medical College of Wisconsin Cancer CenterMilwaukeeWisconsin53226-3596-

Find similar trials in Denver, CO

By condition
Prostate cancer
By specialty
OncologyProstate oncologyMen's healthUrology
By research site
CCOP - Colorado Cancer Research Program, Incorporated· Denver, COEmory University Hospital - Atlanta· Atlanta, GAVeterans Affairs Medical Center - Atlanta (Decatur)· Decatur, GACCOP - Carle Cancer Center· Urbana, ILTufts - New England Medical Center· Boston, MACCOP - Kalamazoo· Kalamazoo, MI

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