Louisville, KY Clinical Trials Report — April 2026

For individuals in Louisville, KY, considering participation in clinical research, April 2026 presents a critical window to join studies before enrollment concludes. Across the city, 30 clinical trials are slated to close within the next 90 days. This urgency is particularly relevant for healthy volunteers, as 3 of these rapidly closing studies are still actively seeking participants without specific health conditions. Those interested in contributing to medical advancements should explore these options promptly.

New Opportunities and Notable Research

This month, Louisville saw the opening of 4 new clinical trials, matching the number that launched in March 2026. These new studies contribute to the city's total of 543 clinical trials currently recruiting across 263 research facilities.

April brings several high-profile new trials to Louisville, KY, including significant Phase 2 and Phase 3 studies from major sponsors. These trials offer participants the chance to engage with cutting-edge treatments for common conditions.

• Eli Lilly and Company is sponsoring NCT07545759, "A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D)." This Phase 2 study, aiming for 531 participants, evaluates the tolerability, side effects, safety, and efficacy of brenipatide (LY3537031) administered subcutaneously (under the skin) for IBS-D.
• Also from Eli Lilly and Company, NCT07545772, "A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Constipation (IBS-C)." This Phase 2 trial, designed for 342 participants, similarly assesses brenipatide (LY3537031) for IBS-C, focusing on its tolerability, safety, and efficacy when administered subcutaneously.
• Novo Nordisk A/S is initiating NCT07509307, "AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain." This important Phase 3 study seeks 400 participants to evaluate the safety and effect of NNC0487-0111, taken as a once-weekly injection under the skin, compared to a placebo, in individuals with excess body weight and knee osteoarthritis.

The new trials this month are exploring conditions such as irritable bowel syndrome (both diarrhea and constipation types), obesity, and knee osteoarthritis. One additional new trial is focused on autism. All 4 new trials are sponsored by industry, with 3 being drug trials and 1 a behavioral trial.

Participation for Healthy Volunteers and Older Adults

While none of the 4 new trials opened this month are accepting healthy volunteers, there are still significant opportunities for those without specific medical conditions to contribute to research. A total of 32 clinical trials are currently recruiting healthy participants in Louisville, including the 3 trials closing within 90 days mentioned earlier. Individuals interested in these opportunities should inquire soon.

Participation in clinical trials is open to a diverse range of individuals. Of the 4 new trials launched this month, 3 include older adults, ensuring that senior populations have ample opportunity to contribute to medical science. No new trials are specifically designed for children, female-only, or male-only participants this month.

Louisville's Leading Research Facilities

Louisville is home to several prominent research institutions and medical centers that consistently run a high volume of clinical trials. These facilities are key destinations for individuals seeking to participate in medical research:

• University of Louisville (68 trials)
• UofL Health Medical Center Northeast (54 trials)
• Norton Cancer Institute (41 trials)
• The James Graham Brown Cancer Center at University of Louisville (40 trials)
• Norton Children's Hospital (35 trials)
• Research Site (28 trials)
• Baptist Health Louisville (25 trials)
• Jewish Hospital (20 trials)
• Saints Mary and Elizabeth Hospital (19 trials)
• University of Louisville Hospital (14 trials)

These institutions offer a broad spectrum of research, from comprehensive medical studies at the University of Louisville and UofL Health, to specialized oncology research at Norton Cancer Institute and The James Graham Brown Cancer Center, and pediatric studies at Norton Children's Hospital.

Conditions with Impending Deadlines

Patients managing certain health conditions also face impending deadlines to join research. Trials focused on various cancers and cardiovascular health are among those with limited time remaining for enrollment. Conditions with trials closing soon include:

• Ovarian cancer (2 trials)
• Appendicitis (1 trial)
• Cardiomyopathies (1 trial)
• Avascular necrosis (1 trial)
• Breast cancer (1 trial)
• Cancer-related pain (1 trial)
• Arrhythmia (1 trial)
• Castrate resistant prostate cancer (1 trial)
• Chronic disease (1 trial)
• Colon cancer (1 trial)

Broadening Your Search: Nearby Options

While Louisville offers a robust array of clinical trial opportunities, individuals may also find options in nearby communities within Kentucky. Cities with active trials include Lexington with 4 trials and Owensboro with 2 trials, providing additional avenues for those interested in participating in medical research.

Looking ahead, the research landscape in Louisville continues to evolve, with a steady stream of new trials opening each month. The past 6 months have seen new trial openings as follows: November 2025 (3), December 2025 (15), January 2026 (8), February 2026 (8), March 2026 (4), and April 2026 (4). This consistent activity ensures ongoing opportunities for residents to contribute to medical advancements.