Paid Clinical Trials in Tennessee

Tennessee has 2,155 paid clinical trials enrolling now across cities including Nashville, Memphis and Knoxville. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Tennessee include Vanderbilt University Medical Center and St. Jude Children's Research Hospital, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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2,157 clinical trials

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A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC

for Non-Small Cell Lung Cancer

Drug: Durvalumab

43 locations incl. Chandler

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05211895·Phase 3·Recruiting

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AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

for Heart Failure

37 locations incl. Fairhope

Sponsor: Cordio Medical

Sex: All·Age: 22+

Code: NCT06378632·Recruiting

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TReatment for ImmUne Mediated PathopHysiology

for Acute Liver Failure

24 locations incl. Los Angeles

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 1 - 18

Code: NCT04862221·Phase 2·Recruiting

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Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

for Adenocarcinoma of the Colon

472 locations incl. Fairbanks

Sponsor: NRG Oncology

Sex: All·Age: 45 - 70

Code: NCT05080673·Recruiting

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Assessment of CCM in HF With Higher Ejection Fraction

for Heart Failure

105 locations incl. Birmingham

Sponsor: Impulse Dynamics

Sex: All·Age: 18+

Code: NCT05064709·Recruiting

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A Study to Test the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures

for Stereotypical Prolonged Seizures

53 locations incl. Phoenix

Sponsor: UCB Biopharma SRL

Sex: All·Age: 12+

Code: NCT05076617·Phase 3·Enrolling By Invitation

A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors

for HER2-positive Advanced Solid Tumor

Drug: DB-1303/BNT323

35 locations incl. Cerritos

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT05150691·Phase 1, Phase 2·Recruiting

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CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

for Diffuse Midline Glioma, H3 K27-Altered

34 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 12 Months - 21

Code: NCT04870944·Phase 1, Phase 2·Recruiting

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Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers

for Advanced Solid Tumor

27 locations incl. Tucson

Sponsor: Synthekine

Sex: All·Age: 18+

Code: NCT05098132·Phase 1, Phase 2·Recruiting

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Open Versus Arthroscopic Stabilization of Shoulder Instability With Subcritical Bone Loss: The OASIS Trial

for Shoulder Dislocation

15 locations incl. Tempe

Sponsor: University of Pittsburgh

Sex: All·Age: 17 - 50

Code: NCT04809064·Recruiting

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Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer

for Head and Neck Cancer

1 location in Nashville

Sponsor: Natalie Lockney

Sex: All·Age: 21+

Code: NCT05156060·Phase 1, Phase 2·Recruiting

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Long-term Extension Study to Assess Safety and Tolerability of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Pediatric Participants (Ages 6-17)

for Migraine

Drug: Ubrogepant

109 locations incl. Huntsville

Sponsor: AbbVie

Sex: All·Age: 6 - 17

Code: NCT05127954·Phase 3·Enrolling By Invitation

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)

for DLBCL

26 locations incl. Glendale

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT05139017·Phase 2, Phase 3·Recruiting

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Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)

for Migraine

Drug: Ubrogepant

125 locations incl. Huntsville

Sponsor: AbbVie

Sex: All·Age: 6 - 17

Code: NCT05125302·Phase 3·Recruiting

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Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD

for AMD

107 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 50 - 89

Code: NCT05407636·Phase 3·Recruiting

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Proact: A Study of REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease

for Type 2 Diabetes Mellitus

79 locations incl. Huntsville

Sponsor: Prokidney

Sex: All·Age: 30 - 80

Code: NCT05099770·Phase 3·Recruiting

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Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II

for Refractory Angina

70 locations incl. Phoenix

Sponsor: Shockwave Medical, Inc.

Sex: All·Age: 18+

Code: NCT05102019·Recruiting

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A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

for Locally Advanced Solid Tumor

20 locations incl. Orange

Sponsor: Nuvalent Inc.

Sex: All·Age: 12+

Code: NCT05118789·Phase 1, Phase 2·Recruiting

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Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans

for Endothelial Dysfunction

1 location in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT04769206·Phase 1, Phase 2·Recruiting

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Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With nAMD

for Neovascular Age-Related Macular Degeneration (nAMD)

16 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: All ages

Code: NCT05210803·Enrolling By Invitation

Long-term Follow-up Study for Participants of Kite-Sponsored Interventional Studies Treated With Gene-Modified Cells

for Solid and Hematological Malignancies

49 locations incl. Gilbert

Sponsor: Kite, A Gilead Company

Sex: All·Age: All ages

Code: NCT05041309·Enrolling By Invitation

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

for Neovascular Age-related Macular Degeneration

Drug: Ranibizumab

51 locations incl. Mesa

Sponsor: Genentech, Inc.

Sex: All·Age: 50+

Code: NCT04853251·Phase 4·Recruiting

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Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

for Renal Cell Carcinoma (RCC)

46 locations incl. Phoenix

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT05176483·Phase 1·Recruiting

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Study of ONO-4685 in Patients With Relapsed or Refractory T Cell Lymphoma

for Relapsed or Refractory T Cell Lymphoma

20 locations incl. Birmingham

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT05079282·Phase 1·Recruiting

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4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration

for Neovascular (Wet) Age-Related Macular Degeneration

24 locations incl. Phoenix

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 50+

Code: NCT05197270·Phase 1, Phase 2·Recruiting

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First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer

for PIK3CA Mutation

24 locations incl. Tucson

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05216432·Phase 1·Recruiting

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A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures

for Stereotypical Prolonged Seizures

66 locations incl. Phoenix

Sponsor: UCB Biopharma SRL

Sex: All·Age: 12+

Code: NCT05077904·Phase 3·Recruiting

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Extension Study of Infigratinib in Children With Achondroplasia (ACH)

for Achondroplasia

8 locations incl. Oakland

Sponsor: QED Therapeutics, a BridgeBio company

Sex: All·Age: 3 - 18

Code: NCT05145010·Phase 2·Enrolling By Invitation

Preserving Fertility After Colorectal Cancer Study

for Colorectal Cancer

1 location in Nashville

Sponsor: Andreana Holowatyj, PhD, MSCI

Sex: All·Age: 18 - 49

Code: NCT05239338·Recruiting

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Active Myeloid Target Compound Combinations in MDS/MPN Overlap Syndromes Overlap Syndromes (ABNL-MARRO)

for MDS/MPN

4 locations incl. Tampa

Sponsor: Michael Savona

Sex: All·Age: 18+

Code: NCT04061421·Phase 1, Phase 2·Recruiting

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Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial

for Breast Cancer

7 locations incl. San Francisco

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT03990896·Phase 2·Recruiting

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Brentuximab Vedotin and Nivolumab for the Treatment of Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

for Relapsed Classic Hodgkin Lymphoma

Drug: Nivolumab

5 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT04561206·Phase 2·Recruiting

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Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

for Breast Cancer, NOS

347 locations incl. Fairbanks

Sponsor: Eastern Cooperative Oncology Group

Sex: All·Age: 18 - 39

Code: NCT05108298·Recruiting

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Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

for Colorectal Carcinoma

21 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 12 Months - 30

Code: NCT04851119·Phase 1, Phase 2·Recruiting

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Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)

for Acute Stroke

35 locations incl. Fairhope

Sponsor: DiaMedica Therapeutics Inc

Sex: All·Age: 18 - 90

Code: NCT05065216·Phase 2, Phase 3·Recruiting

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Desara ® One Single Incision Sling 522 Study

for Stress Urinary Incontinence

15 locations incl. Phoenix

Sponsor: Caldera Medical, Inc.

Sex: Female·Age: 18+

Code: NCT04772131·Recruiting

Apply to this trial

PHACE - Prospective Genetic Investigation

for PHACE Syndrome

1 location in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: All ages

Code: NCT05133245·Enrolling By Invitation

American Lung Association (ALA) Lung Health Cohort

for Lung Diseases

37 locations incl. Birmingham

Sponsor: Johns Hopkins University

Sex: All·Age: 25 - 35·Accepts healthy volunteers

Code: NCT04543461·Recruiting

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Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

for Solid Tumor, Adult

16 locations incl. Gilbert

Sponsor: A2 Biotherapeutics Inc.

Sex: All·Age: 18+

Code: NCT04981119·Recruiting

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Tennessee Alzheimer's Project

for Aging

1 location in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT05372172·Recruiting

Apply to this trial