Paid Clinical Trials in South Carolina

South Carolina has 1,276 paid clinical trials enrolling now across cities including Charleston, Greenville and Columbia. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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1,276 clinical trials

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Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma

for Soft Tissue Sarcoma

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06905132·Phase 2·Recruiting

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Correlation of STN-DBS Induced Visuospatial Changes and Freezing of Gait

for Parkinson Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06994728·Recruiting

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Dosing rTMS for Depression Post-SCI

for Spinal Cord Injuries

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 60

Code: NCT05553353·Recruiting

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A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.

for Advanced Solid Tumors Cancer

11 locations incl. Los Angeles

Sponsor: Nimbus Wadjet, Inc.

Sex: All·Age: 18 - 99

Code: NCT06898450·Phase 1, Phase 2·Recruiting

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tFUS for Memory in mNCD and Healthy Adults

for Mild Neurocognitive Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 50 - 85·Accepts healthy volunteers

Code: NCT06718140·Phase 1·Enrolling By Invitation

A Prospective Interventional Cohort Study to Evaluate the Efficacy and Safety of the AquaLumen, a Novel Filtration Procedure for the Treatment of Open Angle Glaucoma

for Glaucoma Open-Angle

1 location in Charleston

Sponsor: PLU Ophthalmic

Sex: All·Age: 18+

Code: NCT06809647·Not Yet Recruiting

Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment

for Eosinophilic Asthma

34 locations incl. Chandler

Sponsor: AstraZeneca

Sex: All·Age: 12 - 75

Code: NCT06750289·Phase 3·Recruiting

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A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Ulcerative Colitis

for Colitis Ulcerative

19 locations incl. Sun City

Sponsor: Sanofi

Sex: All·Age: 18 - 75

Code: NCT06867094·Phase 2·Recruiting

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Dose Response of Exercise for Arthritis Management

for Arthritis

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18+

Code: NCT06880653·Recruiting

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The Pivotal Study of RapidPulseTM Aspiration System

for Acute Ischemic Stroke

18 locations incl. Torrance

Sponsor: RapidPulse, Inc

Sex: All·Age: 18 - 80

Code: NCT06029491·Recruiting

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A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting

for Ulcerative Colitis

100 locations incl. Birmingham

Sponsor: Takeda

Sex: All·Age: 18 - 80

Code: NCT06581328·Phase 4·Recruiting

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Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

for Metastatic Head and Neck Squamous Cell Carcinoma

177 locations incl. Little Rock

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06589804·Phase 3·Recruiting

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Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

85 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06890598·Phase 3·Recruiting

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DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

for Endometrial Cancer

Drug: Rilvegostomig

60 locations incl. Tucson

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT06989112·Phase 3·Recruiting

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Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors

for Advanced Solid Tumor

Drug: AI-081

19 locations incl. Birmingham

Sponsor: OncoC4, Inc.

Sex: All·Age: 18+

Code: NCT06635785·Phase 1, Phase 2·Recruiting

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Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids

for Asthma

55 locations incl. Bakersfield

Sponsor: AstraZeneca

Sex: All·Age: 18 - 75

Code: NCT06932263·Phase 2·Recruiting

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A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)

for Chronic Obstructive Pulmonary Disease (COPD)

68 locations incl. Cullman

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06878261·Phase 3·Recruiting

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Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma

for Pleuropulmonary Blastoma

76 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT06647953·Phase 3·Recruiting

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Efficacy of Fusidic Acid 1% in the Treatment of Bacterial Conjunctivitis

for Bacterial Conjunctivitis

38 locations incl. Little Rock

Sponsor: Baxis Pharmaceuticals, Inc.

Sex: All·Age: All ages

Code: NCT06911424·Phase 3·Recruiting

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A Phase 1 Study of BHV-1530 in Advanced Solid Tumors

for Solid Tumor

13 locations incl. Denver

Sponsor: Biohaven Therapeutics Ltd.

Sex: All·Age: 18+

Code: NCT06874335·Phase 1·Recruiting

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A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

for Psoriasis

Drug: Tirzepatide

40 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06857942·Phase 4·Recruiting

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Targeted Prehabilitation With Physical Exercise and Inspiratory Muscle Training for Elderly Frail Patients Prior to Ventral Hernia Repair

for Frailty

1 location in Greenville

Sponsor: Prisma Health-Upstate

Sex: All·Age: 65+

Code: NCT06874413·Enrolling By Invitation

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

for Chronic Obstructive Pulmonary Disease (COPD)

67 locations incl. Foley

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06883305·Phase 3·Recruiting

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A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma

for Plasma Cell Myeloma Refractory

34 locations incl. Phoenix

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06356571·Phase 2·Recruiting

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APPROVE Trial: Evaluating a Prescription Digital Therapeutic for Treatment of OAB in Women

for Overactive Bladder (OAB)

10 locations incl. Birmingham

Sponsor: Medstar Health Research Institute

Sex: Female·Age: 22+

Code: NCT06797245·Recruiting

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A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

for Moderately to Severely Active Crohns Disease

Drug: Afimkibart

92 locations incl. Dothan

Sponsor: Hoffmann-La Roche

Sex: All·Age: 16 - 80

Code: NCT06819878·Phase 3·Recruiting

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Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course

for Post Traumatic Stress Disorder

4 locations incl. Phoenix

Sponsor: United States Department of Defense

Sex: All·Age: 18+

Code: NCT06957067·Recruiting

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Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

for Clear Cell Renal Cell Carcinoma

414 locations incl. Phoenix

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06661720·Phase 3·Recruiting

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Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

for Heart Failure

Drug: Dapagliflozin

194 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 40+

Code: NCT06677060·Phase 3·Recruiting

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Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy

for Lower Back Pain

1 location in Summerville

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06540456·Enrolling By Invitation

A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer

55 locations incl. Birmingham

Sponsor: Celgene

Sex: Male·Age: 18+

Code: NCT06764485·Phase 3·Recruiting

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Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

for Fallopian Tube Endometrioid Adenocarcinoma

Drug: Bevacizumab

658 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06580314·Phase 3·Recruiting

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A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

for Relapsed or Refractory Multiple Myeloma (RRMM)

22 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06615479·Phase 3·Recruiting

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Alleviant ALLAY-HFrEF Study

for Heart Failure

35 locations incl. Los Angeles

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 18+

Code: NCT06812533·Enrolling By Invitation

52 Week Study + 24-Month Long-Term Extension of Safety, PK, & Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents With Hypogonadism

for Hypogonadism, Male

20 locations incl. Los Angeles

Sponsor: Halozyme Therapeutics

Sex: Male·Age: 12 - 17

Code: NCT06689085·Phase 3·Recruiting

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Phase 2 Study of ALXN2030 in Patients With Antibody-Mediated Rejection After Kidney Transplantation

for Antibody-Mediated Rejection

23 locations incl. Birmingham

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18 - 75

Code: NCT06744647·Phase 2·Recruiting

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Increasing Affordable Fruits and Vegetables for Families With Food Insecurity

for Diet

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 2 - 10·Accepts healthy volunteers

Code: NCT06828445·Phase 1·Recruiting

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Dose-Ranging Safety, Tolerability, and Efficacy Study of AZD2373 in Participants With APOL1-Mediated Kidney Disease

for APOL1-Mediated Kidney Disease

67 locations incl. Alabaster

Sponsor: AstraZeneca

Sex: All·Age: 18 - 65

Code: NCT06824987·Phase 2·Recruiting

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A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure

for Chronic Kidney Disease and Hypertension

Drug: Dapagliflozin

132 locations incl. Fairhope

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06742723·Phase 3·Recruiting

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Integrated Treatment for Opioid Use Disorder and PTSD

for Opioid Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 70

Code: NCT06641115·Recruiting

Apply to this trial