Correlation of STN-DBS Induced Visuospatial Changes and Freezing of Gait

Part of paid clinical trials in Charleston, South Carolina.

Sponsor
Medical University of South Carolina
Study ID
NCT06994728
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Left STN-DBS on, right STN-DBS off first — DEVICE
    There will not be any change to baseline DBS stimulation settings, only each side will be sequentially turned off during cognitive and freezing of gait assessments.
  • Right STN-DBS on, left STN-DBS off first — DEVICE
    There will not be any change to baseline DBS stimulation settings, only each side will be sequentially turned off during cognitive and freezing of gait assessments.

Study Details

The purpose of this research is to determine how deep brain stimulation (DBS) for Parkinson's disease affects attention and visuospatial function. Additionally, this study will evaluate how deficits in visual attention are associated with freezing of gait (FOG) in Parkinson's disease. There is currently no reliable treatment for FOG and little is understood about the underlying reason this occurs. Some recent research has found that stimulating the right side of the brain seems to improve FOG. The right side of the brain is also paramount for visual attention, which is why investigators are conducting this study.

Key Dates

Start date
Apr 1, 2025
Status verified
May 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
12 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Active Comparator: Left STN-DBS on, right STN-DBS off first
    STN-DBS will be turned off sequentially for each side, in this group beginning with left STN-DBS on and right STN-DBS off. This will then be followed by the corollary.
  • Active Comparator: Right STN-DBS on, left STN-DBS off first
    STN-DBS will be turned off sequentially for each side, in this group beginning with right STN-DBS on and left STN-DBS off. This will then be followed by the corollary.

Primary Outcome Measure

Characterize the individual impact of lateralized STN DBS stimulation on freezing of gait in Parkinson's disease [ Time Frame: 1 hour ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Medical University of South CarolinaCharlestonSouth Carolina29403
Nathan DeTurk, MD, MBA
[email protected]
843-792-3221
Nathan DeTurk, MD, MBA (PRINCIPAL_INVESTIGATOR)

Find similar trials in Charleston, SC

By condition
Parkinson's disease
By specialty
NeurologyBrain disorders
By research site
Medical University of South Carolina· Charleston, SC

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