tFUS for Memory in mNCD and Healthy Adults

Part of paid clinical trials in Charleston, South Carolina.

Sponsor
Medical University of South Carolina
Study ID
NCT06718140
Phase
PHASE1
Status
Enrolling By Invitation

Conditions

  • Healthy Aging
  • Mild Neurocognitive Disorder

Eligibility Criteria

Sex
ALL
Age
50 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • Transcranial Focused Ultrasound — DEVICE
    Using MRI-guided targeting, we will administer focused ultrasound to one of the 4 brain locations

Study Details

Dementia is an ongoing and growing public health crisis in the US and worldwide. The purpose of this study is to examine a form of noninvasive brain stimulation called transcranial focused ultrasound (tFUS) to the hippocampus with the goal of improving memory.

Key Dates

Start date
Mar 30, 2025
Status verified
Nov 2025
Primary completion
Dec 1, 2026
Completion
Dec 1, 2027

Study Design

Enrollment
25 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Focused Ultrasound to Location A
    Focused Ultrasound will be administered to location A as condition 1. Stimulation will last 1-10 minutes
  • Experimental: Focused Ultrasound to Location B
    Focused Ultrasound will be administered to location B as condition 2. Stimulation will last 1-10 minutes
  • Experimental: Focused Ultrasound to Location C
    Focused Ultrasound will be administered to location C as condition 3. Stimulation will last 1-10 minutes
  • Sham Comparator: Focused Ultrasound to Location D
    Focused Ultrasound will be administered to location D as condition 4. Stimulation will last 1-10 minutes

Primary Outcome Measure

Face Name Associative Memory Task (Episodic Memory) effects [ Time Frame: Pre- to post-stimulation (within approximately a 1 hour time period) ]

Locations (1)

FacilityCityStateZIPSite coordinators
Medical University of South CarolinaCharlestonSouth Carolina29414-

Find similar trials in Charleston, SC

By research site
Medical University of South Carolina· Charleston, SC

Related Studies