Clinical Trials at Mayo Clinic in Rochester

As of June 2026, 426 paid clinical trials are recruiting at Mayo Clinic in Rochester, located at 1216 2ND ST SW, ROCHESTER, MN 55902-1906, phone (507) 255-5123 in Rochester, Minnesota. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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426 clinical trials at Mayo Clinic in Rochester

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3D Ultrasound Breast Imaging

for Breast Tumor

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT04692818·Recruiting

Apply to this trial

Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

for Breast Cancer, NOS

347 locations incl. Fairbanks

Sponsor: Eastern Cooperative Oncology Group

Sex: All·Age: 18 - 39

Code: NCT05108298·Recruiting

Apply to this trial

Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough

for Refractory Chronic Cough

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 75

Code: NCT05110144·Phase 2·Recruiting

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Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related Cough

for Interstitial Lung Disease

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 75

Code: NCT05120934·Phase 2·Recruiting

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Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot and Other Congenital Heart Diseases

for Tetralogy of Fallot

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05122962·Recruiting

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Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study

for Diffuse Midline Glioma, H3 K27M-Mutant

2 locations incl. Phoenix

Sponsor: Mayo Clinic

Sex: All·Age: 1+

Code: NCT05077735·Phase 2·Recruiting

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Dexmedetomidine for Intraoperative Shivering in Scheduled Elective Cesarean Delivery

for Shivering

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT04730609·Phase 4·Recruiting

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A Study to Evaluate Non-significant Risk Operation Magnetic Resonance Imaging for MRI Guided Ablation

for Healthy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04880226·Recruiting

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Molecular Breast Imaging Guidance for Breast Biopsy for Patients With Breast Abnormalities

for Breast Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT06058650·Recruiting

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Shear-wave Elastography Compared to Respiratory Function Testing

for Respiratory Function Loss

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04959526·Recruiting

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A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

for Central Nervous System Nongerminomatous Germ Cell Tumor

149 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT04684368·Phase 2·Recruiting

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A Prospective Registry for Patients at High-Risk for Pancreatic Cancer

for Pancreatic Cancer

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06151223·Recruiting

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Testing the Addition of Abemaciclib to Olaparib for Women With Recurrent Ovarian Cancer

for Recurrent Ovarian High Grade Serous Adenocarcinoma

27 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT04633239·Phase 1·Recruiting

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De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

for Stage I Breast Cancer

812 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 50 - 70

Code: NCT04852887·Phase 3·Recruiting

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APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

for Pancreatic Acinar Cell Carcinoma

452 locations incl. Anchorage

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04858334·Phase 2·Recruiting

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Prospective Use of Philips iSuite for Interventional Procedures

for Cancer

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 90

Code: NCT03432936·Enrolling By Invitation

Concomitant Renal and Urinary Bladder Allograft Transplantation

for Chronic Kidney Diseases

2 locations incl. Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 1 - 60

Code: NCT04626167·EARLY_Phase 1·Recruiting

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A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

for Healthy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04984473·Recruiting

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Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer

for Metastatic Malignant Solid Neoplasm

7 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04585958·Phase 1·Recruiting

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Great Saphenous Vein Anatomy at the Proximal Medial Thigh as a Potential Site for Rescue Venous Access

for Anatomy of the GSV for Rescue Peripheral IV Access

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04922606·Enrolling By Invitation

Immune Profile of Acute Myeloid Leukemia Patients Receiving Azacitidine Plus Venetoclax Induction Chemotherapy

for Acute Myeloid Leukemia

Drug: Venetoclax

3 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06279572·Recruiting

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Evaluating the Association Among Changes in Gut Microbiome, Fatigue, and Chemotherapy-Induced Nausea in Early Stage Breast Cancer

for Chemotherapy-Related Nausea and/or Vomiting

5 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 20+

Code: NCT05417867·Recruiting

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Targeting Neuroinflammation as a Contributing Pathology in Alzheimer's Disease Dementia and Related Dementias

for Lewy Body Dementia (LBD)

1 location in Rochester

Sponsor: Val Lowe

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT04786223·Phase 2·Enrolling By Invitation

Assessment of Carpal Tunnel Syndrome by Shearwave Elastography

for Carpal Tunnel Syndrome

2 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 100

Code: NCT04804293·Enrolling By Invitation

Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

for Primary Sclerosing Cholangitis

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT04753996·Recruiting

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Ultrasonic Perfusion Imaging in Post-mastectomy Irradiated Patients

for Breast Reconstruction

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT04992650·Enrolling By Invitation

Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

for Plasma Cell Myeloma

642 locations incl. Anchorage

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT04566328·Phase 3·Recruiting

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Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction

for Gastroesophageal Reflux

2 locations incl. Orlando

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04411823·Recruiting

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Neurostimulation for Treatment of Chronic Upper Limb Pain After Brachial Plexus Injury

for Brachial Plexus Injury

2 locations incl. Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04733599·Recruiting

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Mediterranean Diet Post-liver Transplantation

for Liver Transplantation

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04672863·Recruiting

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Ommaya Reservoir Placement for Brain Tumor Biomarker Access

for Brain Tumor

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04692337·Recruiting

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Cerebrospinal Fluid Biomarkers for Brain Tumors

for Central Nervous System Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: All ages

Code: NCT04692324·Recruiting

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Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial

for Extensive Stage Lung Small Cell Carcinoma

Drug: Atezolizumab

416 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04402788·Phase 2, Phase 3·Recruiting

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Prospective Sinonasal Cancer Multi-institution Study

for Sinonasal Carcinoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 30 Days - 99

Code: NCT04755855·Recruiting

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Comparison of Proton or Intensity Modulated Radiation Therapy After Surgery for Endometrial or Cervical Cancer

for Cervical Carcinoma

3 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT04567771·Recruiting

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Rare and Undiagnosed Disease Research Biorepository

for Undiagnosed Disease

3 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04703179·Enrolling By Invitation

A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

for Anaplastic Kidney Wilms Tumor

177 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT04322318·Phase 2·Recruiting

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The Olmsted NAFLD Epidemiology Study (TONES)

for Non-Alcoholic Fatty Liver Disease

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04365855·Recruiting

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Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

for Buccal Mucosa Squamous Cell Carcinoma

105 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT04333537·Phase 2, Phase 3·Recruiting

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A Vaccine (MV-s-NAP) for the Treatment of Patients With Invasive Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04521764·Phase 1·Recruiting

Apply to this trial