Paid Clinical Trials in Philadelphia, PA

As of June 2026, 2,086 paid clinical trials are recruiting in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,086 clinical trials

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A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation

for KRAS-mutant Non-small Cell Lung Cancer (NSCLC)

7 locations incl. Sarasota

Sponsor: Kestrel Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07458347·Phase 1·Recruiting

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AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

for Obesity

Drug: NNC0487-0111

13 locations incl. Anniston

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07503210·Phase 3·Recruiting

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Allergy Delabeling in Antibiotic Stewardship - Intervention

for Beta Lactam Allergy

1 location in Philadelphia

Sponsor: Ebbing Lautenbach

Sex: All·Age: 18+

Code: NCT07133074·Recruiting

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Study to Evaluate Tulisokibart in Adults With Psoriatic Arthritis (MK-7240-015)

for Psoriatic Arthritis

Drug: Tulisokibart

15 locations incl. Sun City

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18 - 80

Code: NCT07486960·Phase 2·Recruiting

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In-Shoe Loadsol Force Analysis Study LC1 Fractures

for Geriatric Pelvic Ring Fractures

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 65+

Code: NCT07608107·Recruiting

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A Study of Azenosertib (ZN-c3) Versus Investigator's Choice Chemotherapy in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression

for Ovarian Cancer

11 locations incl. Phoenix

Sponsor: K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Sex: Female·Age: 18+

Code: NCT07546500·Phase 3·Recruiting

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Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention

for Sepsis

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 Month - 17

Code: NCT07084129·Phase 1·Recruiting

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A Study to Evaluate Safety, Tolerability, and Efficacy of AB-1009 Gene Therapy (GAA Gene) in Adult Participants With Late Onset Pompe Disease (PROGRESS-GT LOPD)

for Pompe Disease (Late-onset)

9 locations incl. Phoenix

Sponsor: AskBio Inc

Sex: All·Age: 18+

Code: NCT07282847·Phase 1, Phase 2·Recruiting

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Consolidative Metastasis and Primary Directed Therapy (MPDT) for Renal Cell Carcinoma (RCC)

for Renal Cell Carcinoma

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06770855·Not Yet Recruiting

Menopausal HT for Women Living With HIV (HoT)

for HIV Infection

23 locations incl. Birmingham

Sponsor: Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

Sex: Female·Age: 40 - 60

Code: NCT06856174·Phase 4·Recruiting

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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

for Solid Tumors

Drug: INCB161734

68 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07522073·Phase 3·Recruiting

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Testing a Measurement Feedback App to Improve Data Quality, Supervision & Outcomes in Behavioral Health

for Autism

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07042347·Recruiting

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Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)

for Atrial Fibrillation (AF)

22 locations incl. Birmingham

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18+

Code: NCT07298473·Recruiting

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Neoadjuvant CADI-05 in Combination With Pembrolizumab for Surgically Resectable Locally Advanced Head and Neck Squamous Cell Carcinomas

for Squamous Cell Carcinoma of Head and Neck

2 locations incl. Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT07455032·Phase 1·Recruiting

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A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively

for Schizophrenia

Drug: KarXT

19 locations incl. Anaheim

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 5 - 17

Code: NCT07424404·Phase 3·Recruiting

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Nutrition Intervention for Pancreatic Cancer

for Pancreatic Ductal Adenocarcinoma (PDAC)

2 locations incl. Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 18+

Code: NCT07554560·Recruiting

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Conversational AI Platform for Early Pregnancy Care City-wide Recruitment: A Feasibility Study

for Early Pregnancy

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 15+

Code: NCT07197892·Recruiting

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Early General Anesthesia to Limit Experiences of Trauma During Cesarean Section-Pilot Study

for Cesarean Section

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 18+

Code: NCT07334418·Recruiting

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Short Course Radiotherapy

for Central Nervous System Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: Up to 21

Code: NCT07147179·Recruiting

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Targeting Ischemia-Induced Autophagy Dependence in Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 location in Philadelphia

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05842174·Phase 1, Phase 2·Recruiting

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Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine

for Major Depressive Disorder (MDD)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 25 - 65

Code: NCT06788249·EARLY_Phase 1·Recruiting

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INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery

for Heart Failure

7 locations incl. Tampa

Sponsor: Abiomed Inc.

Sex: All·Age: 18 - 80

Code: NCT06965504·Not Yet Recruiting

A Multi-Site Hybrid Type I Effectiveness-Implementation Randomized Trial of an Emergency Care Action Plan for Infants With Medical Complexity

for Chronic Disease Management

4 locations incl. Aurora

Sponsor: University of Vermont

Sex: All·Age: 0 Months - 6 Months

Code: NCT06993129·Not Yet Recruiting

Bowel Continence Across the Lifespan in People With Spina Bifida

for Spina Bifida

24 locations incl. Birmingham

Sponsor: David Chu

Sex: All·Age: 5+

Code: NCT07390318·Recruiting

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A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

for Myelodysplastic Syndrome

18 locations incl. Orange

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT07422480·Phase 3·Recruiting

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Engaging M-health for Symptom Monitoring and Health Promotion for Women on Endocrine Therapy for Breast Cancer (EmSHAPE)

for Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 18+

Code: NCT07454499·Not Yet Recruiting

Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases

for Systemic Lupus Erythematosus

1 location in Philadelphia

Sponsor: Stephan Grupp MD PhD

Sex: All·Age: 8 - 25

Code: NCT05029336·Phase 2·Recruiting

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From Kitchen to Clinic

for Pediatric Cancer

1 location in Philadelphia

Sponsor: Drexel University

Sex: All·Age: 5 - 21

Code: NCT07454902·Not Yet Recruiting

Immune Modulation During Palynziq® Treatment in Adults (IMPALA)

for Phenylketonuria

12 locations incl. Los Angeles

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: 18 - 65

Code: NCT07477691·Phase 4·Not Yet Recruiting

Evaluation of the Safety and Efficacy of Abenacianine (VGT-309) to Identify Cancer in Subjects Undergoing Surgery for Cancer in the Lung

for Lung Cancer

8 locations incl. Duarte

Sponsor: Vergent Bioscience, Inc.

Sex: All·Age: 18+

Code: NCT07499674·Phase 3·Recruiting

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Virtual Reality in End Stage Kidney Disease

for End Stage Kidney Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT06356168·Recruiting

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Phase II Study of Platinum/Etoposide Plus Ivonescimab for Extensive-Stage Small Cell Lung Cancer

for Extensive Stage Lung Small Cell Cancer

Drug: Ivonescimab

6 locations incl. New Brunswick

Sponsor: PrECOG, LLC.

Sex: All·Age: 18+

Code: NCT07057791·Phase 2·Recruiting

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Streamlining Telehealth for Expanded PrEP Utilization Through Community Partnerships

for HIV

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT07246057·Recruiting

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Neuralert Stroke Monitor Trial

for Surgery

1 location in Philadelphia

Sponsor: Neuralert Technologies LLC

Sex: All·Age: 22+

Code: NCT07362303·Recruiting

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Clinical Trial to Evaluate the Safety and Immunogenicity of the V2 Apex-Directed Immunogens DV201P-RNA and DV202B1-RNA in Adult Participants Without HIV

for HIV

7 locations incl. Atlanta

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07390474·Phase 1·Recruiting

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A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease

for Huntington Disease

9 locations incl. Englewood

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 21 - 70

Code: NCT07326709·Phase 3·Recruiting

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Kidney Transplant Improvement Through New Exercise Training to Increase Capacity

for Chronic Kidney Disease 5D

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 60+

Code: NCT07446296·Recruiting

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Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial

for Cardiovascular Disease

Drug: Olpasiran

6 locations incl. Bridgeport

Sponsor: Amgen

Sex: All·Age: 35 - 80

Code: NCT07293260·Phase 3·Recruiting

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Application of Contrast-enhanced Ultrasound in Monitoring Soft Tissue Sarcoma Response to Neoadjuvant Radiotherapy

for Soft Tissue Sarcoma

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT07436364·EARLY_Phase 1·Recruiting

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First Time in Human (FTIH) Study to Investigate the Safety and Preliminary Activity of GSK5533524 Alone or in Combination in Adult Participants With Advanced Solid Tumors

for Neoplasms

2 locations incl. Philadelphia

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT07438782·Phase 1·Recruiting

Apply to this trial