Kidney Transplant Improvement Through New Exercise Training to Increase Capacity

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
University of Pennsylvania
Study ID
NCT07446296
Status
Recruiting
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Conditions

  • Chronic Kidney Disease 5D
  • Chronic Kidney Disease Stage 4
  • Chronic Kidney Disease Stage 5
  • Exercise Theraphy
  • Kidney Failure
  • Kidney Failure,Chronic
  • Kidney Transplantation
  • Renal Insufficiency Chronic
  • Transplant Candidate
  • Waiting List

Eligibility Criteria

Sex
ALL
Age
60 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Exercise Rehabilitation Program with Physical Activity Tracker — BEHAVIORAL
    Participants in this arm will continue to receive their usual pre-transplant care and will also take part in a 12-week, home-based exercise prehabilitation program. Participants will receive a wrist-worn physical activity tracker and access to an online exercise platform designed for people with kidney disease. The program includes live and on-demand exercise classes that focus on light-to-moderate intensity aerobic and resistance exercises. Participants will be asked to complete at least two exercise classes per week. The intervention is delivered remotely, and participants will complete a brief virtual orientation before starting the program. The participants will receive reminders and feedback from the study team about their exercise and physical activity engagement. After the 12 week period, this group will be asked to continue to participate in the exercise program but without study reminders or feedback related to their exercise.
  • Active control — OTHER
    Participants continue standard pre-transplant care provided by the transplant center and to wear a wrist worn activity tracker to measure daily step counts/physical activity.

Study Details

The goal of this clinical trial is to learn if a home-based exercise program can be safely and feasibly used to improve physical activity and physical function in adults waiting for a kidney transplant. The study will also learn how acceptable and useful this program is for participants. The main questions it aims to answer are: * Can a remote exercise program be delivered successfully to people on the kidney transplant waiting list? * Do participants follow the exercise program and wear a physical activity tracker as asked? * Is the program safe and well tolerated? Researchers will compare two groups to see if the exercise program leads to higher physical activity and better physical function: * Usual pre-transplant care with a physical activity tracker * Usual pre-transplant care plus an online exercise program Participants will: * Wear a wrist activity tracker to measure daily physical activity * Complete a one-week baseline period before being assigned to a study group * Be randomly assigned (like flipping a coin) to one of two groups * If assigned to the exercise group, take part in online exercise classes at home for 12 weeks with reminders and feedback, and then another 12 weeks without reminders and feedback * Answer questionnaires about their health, activity, and experience in the study This study may help researchers learn how to better support people waiting for kidney transplant through safe, home-based exercise programs.

Key Dates

Start date
Mar 24, 2026
Status verified
May 2026
Primary completion
Mar 31, 2028
Completion
May 31, 2028

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE

Arms

  • Other: Usual Care with Physical Activity Tracker
    Participants in this arm will continue to receive their usual pre-transplant care provided by the transplant center. In addition, participants will receive a wrist-worn physical activity tracker to measure daily activity, including step counts. Participants will be asked to wear the activity tracker throughout the study period, but they will not receive structured exercise programming or exercise-related coaching as part of the study.
  • Experimental: Exercise Prehabilitation Program with Physical Activity Tracker
    Participants in this arm will continue to receive their usual pre-transplant care and will also take part in a 12-week, home-based exercise prehabilitation program. Participants will receive a wrist-worn physical activity tracker and access to an online exercise platform designed for people with kidney disease. The program includes live and on-demand exercise classes that focus on light-to-moderate intensity aerobic and resistance exercises. Participants will be asked to complete at least two exercise classes per week. The intervention is delivered remotely, and participants will complete a brief virtual orientation before starting the program.

Primary Outcome Measure

Enrollment efficiency and Retention [ Time Frame: Enrollment efficiency time period is study duration (anticipate up to 20 moths) and retention is 12 weeks of intervention period ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Perelman Center for Advanced MedicinePhiladelphiaPennsylvania19104
Sarah Schrauben, MD, MS
[email protected]
267-324-7588

Find similar trials in Philadelphia, PA

By research site
Perelman Center for Advanced Medicine· Philadelphia, PA

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