MRI Technical Development and Applications in Kidney Disease

Part of paid clinical trials in Minneapolis, Minnesota.

Sponsor
University of Minnesota
Study ID
NCT02421497
Status
Not Yet Recruiting

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Conditions

  • Chronic Kidney Diseases
  • Cognition Disorders
  • Dialysis
  • Kidney Transplantation

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Study Details

Magnetic resonance imaging (MRI), as a non-invasive and non-contrast enhanced technique, has the potential to improve patient health care and management. The overall objective of proposed project is to: 1. develop, customize, and optimize anatomic and functional MRI methods, 2. explore the use of MRI methods to study CKD and evaluate post-transplant kidneys, and 3. investigate the potential of MRI in the diagnosis, prognosis, and monitoring of the progression of renal dysfunction. In addition to direct studies of the kidney, brain MRI studies will also be performed to identify the cerebrovascular and cognitive effects of chronic renal function deficiency and medical treatment (e.g. hemodialysis and immunosuppression). The brain and kidneys have similar vascular bed, and both are susceptible to vascular injury, which provides the pathological basis for the widely recognized association of reduced renal function with prevalent cerebrovascular diseases (CVDs) and cognitive impairment (CI). The MRI methods in the brain will be applied to explore the origins for widely observed CVDs and prevalent cognitive impairment (CI) in kidney disease patients.

Key Dates

Start date
Jun 30, 2028
Status verified
Apr 2026
Primary completion
Jun 30, 2029
Completion
Dec 30, 2029

Study Design

Enrollment
180 participants (estimated)

Arms

  • Arm: Normal Healthy Volunteer
  • Arm: Non-CKD Control
  • Arm: Chronic Kidney Disease (CKD)
  • Arm: Dialysis Patients
  • Arm: Renal Transplant Recipients

Primary Outcome Measure

Correspondence of MRI measures with clinical metrics (i.e. eGFR) and routinely assessed cognitive functions from CKD and ESRD patients. [ Time Frame: up to three years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Center for Magnetic Resonance ResearchMinneapolisMinnesota55455
Xiufeng Li, Ph.D.
612-626-2001
Xiufeng Li, Ph.D. (PRINCIPAL_INVESTIGATOR)

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By research site
Center for Magnetic Resonance Research· Minneapolis, MN

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