Clinical Trials at University of Pennsylvania

As of June 2026, 377 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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377 clinical trials at University of Pennsylvania

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Abbott Structural Heart Device Registry

for Heart Diseases

5 locations incl. New Brunswick

Sponsor: Abbott Medical Devices

Sex: All·Age: All ages

Code: NCT06590467·Recruiting

Apply to this trial

TumorGlow Intraoperative Molecular Imaging (IMI)

for Tumor, Solid

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04723810·Phase 1, Phase 2·Recruiting

Apply to this trial

Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation

for Heart Failure

4 locations incl. Detroit

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06291922·Recruiting

Apply to this trial

Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury

for Traumatic Brain Injury

18 locations incl. San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18 - 65

Code: NCT05826912·Phase 2·Enrolling By Invitation

A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

for Head and Neck Squamous Cell Carcinoma

29 locations incl. Duarte

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT06163534·Recruiting

Apply to this trial

DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

for Gestational Diabetes Mellitus

21 locations incl. Tuscaloosa

Sponsor: Ohio State University

Sex: Female·Age: 18+

Code: NCT06445946·Phase 4·Recruiting

Apply to this trial

Long-term Safety and Tolerability of BHV-7000

for Focal Epilepsy

Drug: BHV-7000

115 locations incl. Birmingham

Sponsor: Biohaven Therapeutics Ltd.

Sex: All·Age: 18 - 75

Code: NCT06443463·Phase 2·Enrolling By Invitation

The APS Phenotyping Study

for ARDS

20 locations incl. Fresno

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT06521502·Recruiting

Apply to this trial

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

for Depressive Disorder, Major

Drug: Seltorexant

84 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 74

Code: NCT06559306·Phase 3·Recruiting

Apply to this trial

Improving Outcomes and Reducing Disparities for Patients With Inflammatory Bowel Disease Through Epidemiology and Enhanced Disease Management

for Inflammatory Bowel Diseases

8 locations incl. San Diego

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 13+

Code: NCT06424769·Enrolling By Invitation

FAPI-74 PET/CT in Adults With Fibrosis

for Fibrosis (Morphologic Abnormality)

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 21+

Code: NCT06413355·Phase 1·Recruiting

Apply to this trial

tACS to Enhance Language Abilities

for Stroke

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT06092814·Recruiting

Apply to this trial

Integrating Telehealth to Advance Lung Cancer Screening

for Early Detection of Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 50 - 80

Code: NCT06638554·Recruiting

Apply to this trial

Sildenafil for Microvasculopathy in Chronic TBI

for Traumatic Brain Injury

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 70

Code: NCT05782244·Phase 2·Recruiting

Apply to this trial

Parasitic Ulcer Treatment Trial

for Acanthamoeba Keratitis

13 locations incl. San Francisco

Sponsor: Jeremy Keenan, MD, MPH

Sex: All·Age: 8+

Code: NCT06213649·Phase 3·Recruiting

Apply to this trial

Exploration of Personalized Biomarkers During Neoadjuvant Radiation Therapy for Spinal and Sacral Chordoma

for Chordoma of Spine

2 locations incl. Baltimore

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18+

Code: NCT06463262·Recruiting

Apply to this trial

APPLE: Aspirin to Prevent Pregnancy Loss and Preeclampsia

for Pre-Eclampsia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 18 - 45

Code: NCT06408181·Phase 3·Recruiting

Apply to this trial

Imaging Predictors of Cryolysis Efficacy for Treatment of Obstructive Sleep Apnea

for Obstructive Sleep Apnea of Adult

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT06434558·Enrolling By Invitation

Health Outcomes of Parents With Cystic Fibrosis-Aim 2

for Cystic Fibrosis

18 locations incl. Birmingham

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT06296394·Recruiting

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PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, Sabestomig, and AZD9592 in HNSCC

for Head and Neck Squamous Cell Carcinoma

Drug: Rilvegostomig

7 locations incl. Sacramento

Sponsor: Presage Biosciences

Sex: All·Age: 18+

Code: NCT06366451·EARLY_Phase 1·Recruiting

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A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy

for Neuroendocrine Tumors

4 locations incl. Atlanta

Sponsor: Chimeric Therapeutics

Sex: All·Age: 18 - 85

Code: NCT06055439·Phase 1, Phase 2·Recruiting

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A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast

for Idiopathic Pulmonary Fibrosis

Drug: Nerandomilast

58 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06238622·Phase 3·Recruiting

Apply to this trial

Testing LiverWatch, a Home-Based Remote-Monitoring Intervention for Advanced Liver Disease

for Cirrhosis, Liver

2 locations incl. Ann Arbor

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06136221·Recruiting

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A Clinical Study of the TSX Dental Implant System (Xpresso)

for Tooth Loss

2 locations incl. Columbus

Sponsor: ZimVie

Sex: All·Age: 18+

Code: NCT06571812·Recruiting

Apply to this trial

Platform Clinical Study for Conquering Scleroderma

for Interstitial Lung Disease Due to Systemic Disease

34 locations incl. Birmingham

Sponsor: Scleroderma Research Foundation, Inc.

Sex: All·Age: 18+

Code: NCT06195072·Phase 2·Recruiting

Apply to this trial

IMPRoving Outcomes in Vascular DisEase - Aortic Dissection

for Type B Aortic Dissection

61 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT06087029·Recruiting

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A Double-Blind, Active-Controlled, Multiple-Ascending Dose Study of Aerosolized RSP-1502 in Subjects With CF and Chronic PA Lung Infection

for Cystic Fibrosis Lung

13 locations incl. Tucson

Sponsor: Respirion Pharmaceuticals Pty Ltd

Sex: All·Age: 12+

Code: NCT06016088·Phase 1, Phase 2·Recruiting

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MicroRNAs as Biomarkers for Obstructive Sleep Apnea

for Obstructive Sleep Apnea

2 locations incl. Columbus

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 75

Code: NCT06189755·Recruiting

Apply to this trial

Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]

for Lymphedema of the Head and Neck

2 locations incl. Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06125743·Recruiting

Apply to this trial

Promoting Shared Decision Making for Severe Aortic Stenosis

for Aortic Stenosis

8 locations incl. San Francisco

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65 - 85

Code: NCT06171737·Enrolling By Invitation

Text-Messaging Telehealth and Contingency Management for Opioid Use Disorder Treatment Engagement

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05897788·Recruiting

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A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy

for Focal Epilepsy

Drug: BHV-7000

61 locations incl. Phoenix

Sponsor: Biohaven Therapeutics Ltd.

Sex: All·Age: 18 - 75

Code: NCT06132893·Phase 2, Phase 3·Recruiting

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CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML

for Leukemia, Myeloid, Acute

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05945849·Phase 1·Recruiting

Apply to this trial

A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1)

for Myotonic Dystrophy Type 1 (DM1)

8 locations incl. San Carlos

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 64

Code: NCT06185764·Phase 1, Phase 2·Recruiting

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SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

for Acute Myeloid Leukemia With FLT3/ITD Mutation

4 locations incl. Chapel Hill

Sponsor: Uma Borate

Sex: All·Age: 18+

Code: NCT06222580·Phase 1·Recruiting

Apply to this trial

An Observational Study of Patients With Chronic Liver Disease

for Chronic Liver Disease

10 locations incl. Los Angeles

Sponsor: Target PharmaSolutions, Inc.

Sex: All·Age: 18+

Code: NCT05744713·Enrolling By Invitation

Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503

for Tauopathies

3 locations incl. New Haven

Sponsor: University of Pennsylvania

Sex: All·Age: 40 - 85·Accepts healthy volunteers

Code: NCT06303921·EARLY_Phase 1·Recruiting

Apply to this trial

Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia

for Primary Progressive Aphasia

2 locations incl. Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 50 - 90·Accepts healthy volunteers

Code: NCT05386394·Phase 2·Recruiting

Apply to this trial

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for Advanced Solid Tumors With KRAS G12C Mutations

Drug: FMC-376

15 locations incl. La Jolla

Sponsor: Frontier Medicines Corporation

Sex: All·Age: 18+

Code: NCT06244771·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis

for Antineutrophil Cytoplasmic Antibody-associated Vasculitis

Drug: Avacopan

60 locations incl. Anchorage

Sponsor: Amgen

Sex: All·Age: 18 - 100

Code: NCT06072482·Phase 4·Recruiting

Apply to this trial