tACS to Enhance Language Abilities

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
University of Pennsylvania
Study ID
NCT06092814
Status
Recruiting
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Conditions

  • Aphasia
  • Aphasia, Acquired
  • Stroke

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • Active transcranial alternating current stimulation (tACS) — DEVICE
    Transcranial Alternating Current Stimulation (tACS) is a device that applies a low-intensity electrical current to the brain through electrodes on the scalp.

Study Details

The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests. Researchers will compare the post-stroke aphasia group with aged matched controls to see if brain response to tACS differs between groups.

Key Dates

Start date
Jul 12, 2024
Status verified
Aug 2025
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Active Comparator: real-tACS
    The active stimulation will consist of an alternating current delivered in the alpha frequency band with a peak-to-peak intensity of 4 milliamps (mA) for 20 minutes. Participants will complete sentence completion and verb generation task during stimulation.
  • Placebo Comparator: sham-tACS
    Sham stimulation involves the delivery of 60 seconds of the actual stimulation waveform ("ramp up") which is then gradually reduced to 0 milliamps (mA) ("ramp down"). Participants will complete sentence completion and verb generation task during stimulation.

Primary Outcome Measure

Performance on the Blocked-Cyclic Naming (BCN) Task [ Time Frame: 5-10 minutes after a single session of active (alpha tACS) and sham (fake tACS). ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of PennsylvaniaPhiladelphiaPennsylvania19104
Denise Harvey, PhD
[email protected]
215-573-4336
Daniela Sacchetti, MS
[email protected]
215 573 4336

Find similar trials in Philadelphia, PA

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
University of Pennsylvania· Philadelphia, PA

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