Clinical Trials at University of Pennsylvania

As of June 2026, 377 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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377 clinical trials at University of Pennsylvania

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A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)

for Focal Segmental Glomerulosclerosis

65 locations incl. Alabaster

Sponsor: Boehringer Ingelheim

Sex: All·Age: 12+

Code: NCT07220083·Phase 3·Recruiting

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A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy

for Symptomatic Genetic Dilated Cardiomyopathy

18 locations incl. Birmingham

Sponsor: Kardigan, Inc.

Sex: All·Age: 18+

Code: NCT07210723·Phase 2, Phase 3·Recruiting

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A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary Fibrosis

for Familial Pulmonary Fibrosis

Drug: Nerandomilast

13 locations incl. Los Angeles

Sponsor: Boehringer Ingelheim

Sex: All·Age: 40+

Code: NCT07201922·Phase 3·Recruiting

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A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

29 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07266441·Phase 2·Recruiting

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Light Therapy in End Stage Kidney Disease

for End Stage Renal Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06310161·Recruiting

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Study to Enable New Diagnostics for Pulmonary Microbes in People With CF

for Cystic Fibrosis (CF)

9 locations incl. La Jolla

Sponsor: Chris Goss

Sex: All·Age: 16+

Code: NCT07312734·Not Yet Recruiting

Stelo Real-time Continuous Glucose Monitor Use Postpartum for Lifelong Optimal Wellness

for Gestational Diabetes

3 locations incl. Santa Barbara

Sponsor: Oregon Health and Science University

Sex: Female·Age: 18+

Code: NCT07356986·Not Yet Recruiting

Stress Management and Mindfulness Intervention for Patients With Sickle Cell Disease

for Sickle Cell Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07316478·Recruiting

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Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

for Cigarette Smoking

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT07199517·Recruiting

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Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT

for Perinatal Opioid Use Disorder

2 locations incl. Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: All ages

Code: NCT06969261·Recruiting

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Diagnosing Epilepsy To EffeCT Change

for Epilepsy

18 locations incl. Phoenix

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110337·Recruiting

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Psilocybin on Brain Mechanisms of Motivation in OUD

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 60

Code: NCT06810310·Phase 2·Recruiting

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Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

for Amyotrophic Lateral Sclerosis

7 locations incl. Phoenix

Sponsor: Vector Y Therapeutics

Sex: All·Age: 18+

Code: NCT07287397·Phase 1, Phase 2·Recruiting

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Ruxolitinib in Previously Treated Idiopathic Multicentric Castleman Disease

for Castleman's Disease (CD)

Drug: Ruxolitinib

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 80

Code: NCT07085039·Phase 2·Recruiting

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Menstrual Cycle TMS Plasticity Pilot

for Cortical Activation

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 20 - 40·Accepts healthy volunteers

Code: NCT07180654·Recruiting

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Efficacy and Safety of a Single Dose of LS301-IT for Fluorescence Intraoperative Molecular Imaging (IMI) for Patients Undergoing Lung Cancer Resection for Non Small Cell Lung Cancer

for Non Small Cell Lung Cancer (NSCLC)

2 locations incl. Philadelphia

Sponsor: Integro Theranostics

Sex: All·Age: 18+

Code: NCT07276789·Phase 2·Recruiting

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Evaluating Artificial Intelligence-Based Clinical Decision Support for Sepsis and ARDS

for Sepsis

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07025096·Enrolling By Invitation

Community Discussions and Social Participation

for Social Connectedness

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07013357·Enrolling By Invitation

Different Approaches for CART-EGFR-IL13Ra2 Dosing in Recurrent GBM

for Recurrent Glioblastoma

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07209241·Phase 1·Recruiting

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A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.

for Epithelial Ovarian Cancer

64 locations incl. Birmingham

Sponsor: AbbVie

Sex: Female·Age: 18+

Code: NCT06890338·Phase 2·Recruiting

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TMS for iEEG Monitoring Recordings

for EEG

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 21 - 75

Code: NCT07518745·Enrolling By Invitation

A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

for Lymphoma

14 locations incl. Aurora

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT07015242·Phase 2·Recruiting

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A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks

for Eosinophilic Esophagitis

41 locations incl. Little Rock

Sponsor: Phathom Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06851559·Phase 2·Recruiting

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Study of S-606001 as an Add-on to Enzyme Replacement Therapy (ERT) in Participants With Late-onset Pompe Disease (LOPD)

for Pompe Disease

9 locations incl. Irvine

Sponsor: Shionogi

Sex: All·Age: 18+

Code: NCT07123155·Phase 2·Recruiting

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A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

for Ovarian Neoplasms

20 locations incl. Newport Beach

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07213791·Phase 1·Recruiting

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The GRoceries Aimed at Increasing Nutrition Study

for Type 2 Diabetes

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 45 - 70

Code: NCT07167004·Recruiting

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Wellcome Leap Psilocybin for OUD

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: Anna Rose Childress, Ph.D.

Sex: All·Age: 18 - 60

Code: NCT06786325·Phase 2·Recruiting

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MOv19-BBz CAR T Cells in FRa+ Cancers

for Metastatic Non Small Cell Lung Cancer

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07116057·Phase 1·Recruiting

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Central Vein Sign in Multiple Sclerosis Extension Study

for Multiple Sclerosis

3 locations incl. Los Angeles

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 65

Code: NCT07424027·Recruiting

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Closed Loop and Education for Hypoglycemia Awareness Restoration

for Diabetes Mellitus, Type 1

5 locations incl. La Jolla

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 18 - 75

Code: NCT06325202·Recruiting

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A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease

for Crohn Disease

58 locations incl. Chandler

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07196722·Phase 2, Phase 3·Recruiting

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Accelerometer Measured Early Recovery After Prolapse Surgery

for Pelvic Organ Prolapse

7 locations incl. San Diego

Sponsor: NICHD Pelvic Floor Disorders Network

Sex: Female·Age: 18 - 99

Code: NCT07218016·Recruiting

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Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer

for Metastatic Breast Cancer

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06795529·Recruiting

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A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis

for Colitis, Ulcerative

54 locations incl. Chandler

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 12+

Code: NCT07196748·Phase 3·Recruiting

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AI-informed Colorectal Cancer (CRC) Screening Navigation vs. Standard of Care Among Screening-naive Penn Medicine Patients 45-49 Years Old to Increase CRC Screening Uptake

for Colorectal Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 45 - 49

Code: NCT07230795·Enrolling By Invitation

Real-Time Diagnosis of Life-Threatening Necrotizing Soft Tissue Infections (NSTI) Using Indocyanine Green (ICG) Kinetic Modeling

for Necrotizing Fascitis

8 locations incl. Los Angeles

Sponsor: Eric R. Henderson

Sex: All·Age: 18+

Code: NCT06877793·Recruiting

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Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

for Acute Myeloid Leukemia (AML)

42 locations incl. Gilbert

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT07007312·Phase 3·Recruiting

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Enhancing the Organizational Social Context to Improve Viral Suppression and Retention in HIV Care

for HIV/AIDS

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06462807·Recruiting

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Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

for Solid Tumor Malignancies

13 locations incl. Denver

Sponsor: Tasca Therapeutics

Sex: All·Age: 18+

Code: NCT07030257·Phase 1, Phase 2·Recruiting

Apply to this trial

855303-RNA Biomarker Validation

for Fractures, Bone

7 locations incl. Sacramento

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06872775·Enrolling By Invitation