Menstrual Cycle TMS Plasticity Pilot

Conditions

• Cortical Activation

Eligibility Criteria

Sex

ALL

Age

20 Years - 40 Years

Healthy Volunteers

Accepted

Interventions

• transcranial magnetic stimulation — DEVICE
  Subjects will receive a series of 60 10s trains that will be presented over the course of the \~3.5 min session. Each train will consist of 2 s of stimulation with an 8 s ITI. During the 2 s of stimulation, 10, 50 Hz bursts will be repeated at intervals of 200 ms (5 Hz). iTBS will be administered at 100% of the motor threshold (MT).

Study Details

Aim 1: Assess how menstrual cycle phase affects motor cortex plasticity in females. Aim 2: Compare motor cortex plasticity between males and females across the same time points, identifying potential sex differences in TMS response. Aim 3: Examine associations between serum hormone levels and TMS-induced plasticity within and between sexes.

Key Dates

Start date

Dec 15, 2025

Status verified

Jan 2026

Primary completion

Oct 31, 2028

Completion

Oct 31, 2028

Study Design

Enrollment

100 participants (estimated)

Arms

• Arm: Volunteers
  Single group design

Primary Outcome Measure

Single-pulse TMS [ Time Frame: Will be collected during 3 visits over the course of a 2 month timeframe during different phases of the menstrual cycle (in females). ]

Central Contacts

• Nicholas Balderston, PhD
  12157463058
  [email protected]

Locations (1)

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